LF (N-Term) Antikörper

Antigen: LF (N-Term)

Klonalität: Monoklonal (LFA27)

Wirt: Maus

Reaktivität: Bakterien

Applikation: Western Blot (WB), ELISA

Produktnummer: ABIN305108

Produktbeschreibung

Swiss-Prot: P15917

Immunogen: Highly purified Bacillus anthracis lethal factor.

Isotyp: IgG2a  (Passende Sekundärantikörper)

Klon: LFA27

Beschreibung: Gene: LF, Standard Gene Symbol: LF, Family: Toxin, Synonyms: LF

Spezifität: Recognizes the Lethal Factor of the anthrax toxin. Bacillus anthracis produces a toxin composed of three proteins, the Protective Antigen (PA), the Edema Factor (EF) and the Lethal Factor (LF). The three proteins depend on each other for their toxic effect. Both EF and LF functions intracellularly but are too large to enter the cell through existing channels. The PA is responsible for transporting the EF and LF into cells. The LF acts as an endoprotease, removing the N-terminus of mitogen-activated protein kinase kinases (MAPKK). The kinases are prevented from binding to their substrates, which leads to altered signalling pathways and ultimately to apoptosis. May be used to detect the Lethal Factor of Bacillus anthracis in ELISA assays

Anwendungen

Applikationshinweise: ELISA, WB

Reinigung: Affinity Chromatography

Buffer: PBS, pH 7.4, 0.09% sodium azide.

Lagerung: Long term: -20°C, Short term: -20°C

Beschränkungen: Nur für Forschungszwecke einsetzbar