TNNC1 Antikörper

Antigen: TNNC1

Klonalität: Monoklonal (7B9)

Wirt: Maus

Reaktivität: Human

Applikation: Western Blot (WB), ELISA

Produktnummer: ABIN305098

Produktbeschreibung

Swiss-Prot: P63316

Immunogen: Human slow skeletal troponin C.

Isotyp: IgG1  (Passende Sekundärantikörper)

Klon: 7B9

Beschreibung: Gene: TNNC1, Standard Gene Symbol: TNNC1, Synonyms: TNNC1, CMD1Z, CMH13, TN-C, TNC, TNNC, Troponin c, slow skeletal and cardiac muscles

Spezifität: Recognizes human Troponin C, an 18kD subunit of the Troponin complex found on actin filaments in muscle tissue. Troponin C (TnC) is responsible for binding calcium ions. In the absence of calcium, TnC has an inhibitory action on the actin filaments. When calcium binds to TnC, a conformational change takes place in Troponin I, which in turn causes a change in another associated protein, tropomyosin. Troponin and tropomyosin is repositioned away from the actin filaments, leaving the myosin binding sites available for cross-bridges to form and muscle contraction to occur. Recognizes free cardiac Troponin C and TnC in binary complex with cardiac Troponin I. The antibody does not recognize free cardiac Troponin I or cardiac Troponin T. May be used to detect human Troponin C in ELISA assays.

Anwendungen

Applikationshinweise: ELISA, WB

Reinigung: Affinity Chromatography

Buffer: PBS, pH 7.4, 0.09% sodium azide.

Lagerung: Long term: -20°C, Short term: -20°C

Beschränkungen: Nur für Forschungszwecke einsetzbar