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TIMP1 Antikörper (C-Term)

TIMP1 Reaktivität: Human WB, IHC (p) Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN3044394
  • Target Alle TIMP1 Antikörper anzeigen
    TIMP1 (TIMP Metallopeptidase Inhibitor 1 (TIMP1))
    Bindungsspezifität
    • 18
    • 16
    • 15
    • 15
    • 9
    • 6
    • 5
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 189-207, C-Term
    Reaktivität
    • 134
    • 73
    • 66
    • 24
    • 7
    • 5
    • 5
    • 5
    • 4
    • 2
    • 1
    • 1
    • 1
    Human
    Wirt
    • 123
    • 54
    • 6
    • 1
    • 1
    Kaninchen
    Klonalität
    • 125
    • 59
    Polyklonal
    Konjugat
    • 88
    • 25
    • 17
    • 8
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    Dieser TIMP1 Antikörper ist unkonjugiert
    Applikation
    • 139
    • 71
    • 58
    • 39
    • 26
    • 23
    • 22
    • 22
    • 19
    • 16
    • 10
    • 9
    • 7
    • 6
    • 4
    • 4
    • 4
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Verwendungszweck
    Rabbit IgG polyclonal antibody for Metalloproteinase inhibitor 1(TIMP1) detection. Tested with WB, IHC-P in Human.
    Sequenz
    CLPREPGLCT WQSLRSQIA
    Kreuzreaktivität (Details)
    No cross reactivity with other proteins.
    Produktmerkmale
    Rabbit IgG polyclonal antibody for Metalloproteinase inhibitor 1(TIMP1) detection. Tested with WB, IHC-P in Human.
    Gene Name: TIMP metallopeptidase inhibitor 1
    Protein Name: Metalloproteinase inhibitor 1
    Aufreinigung
    Immunogen affinity purified.
    Immunogen
    A synthetic peptide corresponding to a sequence at the C-terminus of human TIMP-1(189-207aa CLPREPGLCTWQSLRSQIA).
    Isotyp
    IgG
    Top Product
    Discover our top product TIMP1 Primärantikörper
  • Applikationshinweise
    WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human
    IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
    Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.
    Kommentare

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    Konzentration
    500 μg/mL
    Buffer
    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.
    Konservierungsmittel
    Thimerosal (Merthiolate), Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    At -20°C for one year. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20 °C for a longer time.Avoid repeated freezing and thawing.
    Haltbarkeit
    12 months
  • "Retraction: Naringin Alleviates Diabetic Kidney Disease through Inhibiting Oxidative Stress and Inflammatory Reaction." in: PLoS ONE, Vol. 13, Issue 2, pp. e0192465, (2018) (PubMed).

    Wang, Jiang, Xue: "Recombinant human endostatin reduces hypertrophic scar formation in rabbit ear model through down-regulation of VEGF and TIMP-1." in: African health sciences, Vol. 16, Issue 2, pp. 542-53, (2017) (PubMed).

    Li, Li, Zeng, Liu, Yang: "H2S improves renal fibrosis in STZ-induced diabetic rats by ameliorating TGF-β1 expression." in: Renal failure, Vol. 39, Issue 1, pp. 265-272, (2017) (PubMed).

    Fan, Jiang, Li, Fang, Xu, Zheng: "MMP-1/2 and TIMP-1/2 expression levels, and the levels of collagenous and elastic fibers correlate with disease progression in a hamster model of tongue cancer." in: Oncology letters, Vol. 11, Issue 1, pp. 63-68, (2016) (PubMed).

    Di, Nie, Chen: "Matrix metalloproteinase-9 and vascular endothelial growth factor expression change in experimental retinal neovascularization." in: International journal of ophthalmology, Vol. 9, Issue 6, pp. 804-8, (2016) (PubMed).

    Jiang, Han, Li, Yang, Liu: "Carboxymethyl chitosan represses tumor angiogenesis in vitro and in vivo." in: Carbohydrate polymers, Vol. 129, pp. 1-8, (2015) (PubMed).

    Song, Zou, Wang, Yang, Xie, Bi: "Matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 expression in early focal cerebral infarction following urokinase thrombolysis in rats." in: Neural regeneration research, Vol. 7, Issue 17, pp. 1325-30, (2015) (PubMed).

    Deng, Ling, Liu, Zhao, Lv: "Decreased expression of matrix metalloproteinase-1 in the maternal umbilical serum, trophoblasts and decidua leads to preeclampsia." in: Experimental and therapeutic medicine, Vol. 9, Issue 3, pp. 992-998, (2015) (PubMed).

    Yin, Li, Gao, Li, Li: "Andrographolide plays an important role in bleomycin-induced pulmonary fibrosis treatment." in: International journal of clinical and experimental medicine, Vol. 8, Issue 8, pp. 12374-81, (2015) (PubMed).

    Xu, Dai, Liu, Liu, Song, Li, Chen, Lin: "Sanmiao formula inhibits chondrocyte apoptosis and cartilage matrix degradation in a rat model of osteoarthritis." in: Experimental and therapeutic medicine, Vol. 8, Issue 4, pp. 1065-1074, (2014) (PubMed).

    Zhong, Wang, Jian: "Expression of matrix metalloproteinases-8 and -9 and their tissue inhibitor in the condyles of diabetic rats with mandibular advancement." in: Experimental and therapeutic medicine, Vol. 8, Issue 5, pp. 1357-1364, (2014) (PubMed).

    Ma, Ma, Ma, Sun, Yu, Wang, Li, Ding: "The Effects of Uygur Herb Hyssopus officinalis L. on the Process of Airway Remodeling in Asthmatic Mice." in: Evidence-based complementary and alternative medicine : eCAM, Vol. 2014, pp. 710870, (2014) (PubMed).

    Xu, Ling, Zhu, Fan, Zhang: "The effect of 2,3,4',5-tetrahydroxystilbene-2-0-?-D glucoside on neointima formation in a rat artery balloon injury model and its possible mechanisms." in: European journal of pharmacology, Vol. 698, Issue 1-3, pp. 370-8, (2013) (PubMed).

    Jiang, Jin, Li, Zhang, Yang, Yang, Li, Yang, Ma: "Intermittent hypobaric hypoxia promotes atherosclerotic plaque instability in ApoE-deficient mice." in: High altitude medicine & biology, Vol. 14, Issue 2, pp. 175-80, (2013) (PubMed).

    Hu, Wang, Zhao, Hu, Lu, Qin: "Overexpressed C-type natriuretic peptide serves as an early compensatory response to counteract extracellular matrix remodeling in unilateral ureteral obstruction rats." in: Molecular biology reports, Vol. 40, Issue 2, pp. 1429-41, (2013) (PubMed).

    Jin, Jiang, Yang, Zhang, Yang, Zhang, Li, Yang, Ma: "Acipimox attenuates atherosclerosis and enhances plaque stability in ApoE-deficient mice fed a palmitate-rich diet." in: Biochemical and biophysical research communications, Vol. 428, Issue 1, pp. 86-92, (2012) (PubMed).

    Zhao, Xue, Liu, Li, Wang, Li, Wang, Dong, Xue: "Differential effects of sulfated triterpene glycosides, holothurin A1, and 24-dehydroechinoside A, on antimetastasic activity via regulation of the MMP-9 signal pathway." in: Journal of food science, Vol. 75, Issue 9, pp. H280-8, (2011) (PubMed).

    Wu, Zhang, Tang, Li, Chen, Zhang, Deng: "Effect of total saponins of "panax notoginseng root" on aortic intimal hyperplasia and the expressions of cell cycle protein and extracellular matrix in rats." in: Phytomedicine : international journal of phytotherapy and phytopharmacology, Vol. 17, Issue 3-4, pp. 233-40, (2010) (PubMed).

    Liu, Ahmed, Nantajit, Rosenthal, Hai, Li: "Therapeutic effects of alpha-lipoic acid on bleomycin-induced pulmonary fibrosis in rats." in: International journal of molecular medicine, Vol. 19, Issue 6, pp. 865-73, (2007) (PubMed).

    Xue, Zhang, Liu, Wang: "A new ATP-sensitive potassium channel opener protects the kidney from hypertensive damage in spontaneously hypertensive rats." in: The Journal of pharmacology and experimental therapeutics, Vol. 315, Issue 2, pp. 501-9, (2005) (PubMed).

  • Target
    TIMP1 (TIMP Metallopeptidase Inhibitor 1 (TIMP1))
    Andere Bezeichnung
    TIMP1 (TIMP1 Produkte)
    Synonyme
    TIMP-1 antikoerper, TIMP1 antikoerper, DKFZp468A0912 antikoerper, CLGI antikoerper, EPA antikoerper, EPO antikoerper, HCI antikoerper, TIMP antikoerper, Timp antikoerper, Clgi antikoerper, TIMP metallopeptidase inhibitor 1 antikoerper, tissue inhibitor of metalloproteinase 1 antikoerper, TIMP1 antikoerper, Timp1 antikoerper
    Hintergrund
    TIMP metallopeptidase inhibitor 1, also known as TIMP1, a tissue inhibitor of metalloproteinases, is a glycoprotein that is expressed from the several tissues of organisms. This protein a member of the TIMP family. The glycoprotein is a natural inhibitor of the matrix metalloproteinases(MMPs), a group of peptidases involved in degradation of the extracellular matrix. In addition to its inhibitory role against most of the known MMPs, the encoded protein is able to promote cell proliferation in a wide range of cell types, and may also have an anti-apoptotic function. Transcription of this gene is highly inducible in response to many cytokines and hormones. TIMP was found to be located about 22 cM proximal to OTC(300461).

    Synonyms: Clgi antibody|Collagenase inhibitor antibody|EPA antibody|EPO antibody|Erythroid Potentiating Activity antibody|Erythroid-potentiating activity antibody|Fibroblast collagenase inhibitor antibody|FLJ90373 antibody|HCI antibody|Human Collagenase Inhibitor antibody|Metalloproteinase inhibitor 1 antibody|Metalloproteinase inhibitor 1 precursor antibody|OTTHUMP00000023214 antibody|TIMP 1 antibody|TIMP antibody|TIMP metallopeptidase inhibitor 1 antibody|TIMP-1 antibody|Timp1 antibody|TIMP1 protein antibody|TIMP1_HUMAN antibody|Tissue Inhibitor of Metalloproteinase 1 antibody|Tissue inhibitor of metalloproteinases 1 antibody|Tissue inhibitor of metalloproteinases antibody|Ttissue inhibitor of metalloproteinase 1 erythroid potentiating activity collagenase inhibitor antibody
    UniProt
    P01033
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