TIMP2 Antikörper (C-Term)

Produktnummer ABIN3044332

Produktdetails anti-TIMP2 Antikörper

Target: TIMP2 (Metalloproteinase Inhibitor 2 (TIMP2))

Bindungsspezifität: AA 205-220, C-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TIMP2 Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Verwendungszweck: Rabbit IgG polyclonal antibody for Metalloproteinase inhibitor 2(TIMP2) detection. Tested with IHC-P, ELISA in Human,Mouse,Rat.

Sequenz: RGAAPPKQEF LDIEDP

Kreuzreaktivität (Details): Predicted Cross Reactivity: mouse, rat
No cross reactivity with other proteins.
Predicted Cross Reactivity: Species predicted to be fit for the product based on sequence similarities.

Produktmerkmale: Rabbit IgG polyclonal antibody for Metalloproteinase inhibitor 2(TIMP2) detection. Tested with IHC-P, ELISA in Human,Mouse,Rat.
Gene Name: TIMP metallopeptidase inhibitor 2
Protein Name: Metalloproteinase inhibitor 2

Aufreinigung: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human TIMP2(205-220aa RGAAPPKQEFLDIEDP), identical to the related mouse and rat sequences.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Predicted Species: Mouse, Rat, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
ELISA: Concentration: 0.1-0.5 μg/mL, Tested Species: Human

Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.

Kommentare:

Antibody can be supported by ABIN921231 in IHC(P).

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

Konservierungsmittel: Thimerosal (Merthiolate), Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Referenzen für anti-TIMP2 Antikörper (ABIN3044332)

Tang, Pei, Yang, Wang, Wang, Gao, Li, Yang, Yang: "The inhibition of calpains ameliorates vascular restenosis through MMP2/TGF-β1 pathway." in: Scientific reports, Vol. 6, pp. 29975, (2018) (PubMed).

Liu, Li, Liang, Li, Jiang, Chu, Yang: "Hydrogen sulfide attenuates myocardial fibrosis in diabetic rats through the JAK/STAT signaling pathway." in: International journal of molecular medicine, Vol. 41, Issue 4, pp. 1867-1876, (2018) (PubMed).

Zeng, Li, Li, Li, Xiao, Chu, Yang: "Effect of Novel Gasotransmitter hydrogen sulfide on renal fibrosis and connexins expression in diabetic rats." in: Bioengineered, Vol. 7, Issue 5, pp. 314-320, (2017) (PubMed).

et al.: "Erratum: Long-term intravenous administration of carboxylated single-walled carbon nanotubes induces persistent accumulation in the lungs and pulmonary fibrosis via the nuclear factor-kappa B pathway ..." in: International journal of nanomedicine, Vol. 12, pp. 1515, (2017) (PubMed).

Fan, Jiang, Li, Fang, Xu, Zheng: "MMP-1/2 and TIMP-1/2 expression levels, and the levels of collagenous and elastic fibers correlate with disease progression in a hamster model of tongue cancer." in: Oncology letters, Vol. 11, Issue 1, pp. 63-68, (2016) (PubMed).

Zhou, Zhang, Gao, Zhang, Kong: "Inhibition of Zymosan-Induced Inflammatory Factors Expression by ATRA Nanostructured Lipid Carriers." in: Journal of ophthalmology, Vol. 2016, pp. 4952340, (2016) (PubMed).

Ye, Wang, Zhang, Song, Yang, Li, Li, Su, Yang, Ma: "Over-expression of calpastatin inhibits calpain activation and attenuates post-infarction myocardial remodeling." in: PLoS ONE, Vol. 10, Issue 3, pp. e0120178, (2015) (PubMed).

Wu, Zhang, Qu, Feng, Tian, Zhang, Li, Sun, Liu: "MiR-19a is correlated with prognosis and apoptosis of laryngeal squamous cell carcinoma by regulating TIMP-2 expression." in: International journal of clinical and experimental pathology, Vol. 7, Issue 1, pp. 56-63, (2014) (PubMed).

Xu, Ling, Zhu, Fan, Zhang: "The effect of 2,3,4',5-tetrahydroxystilbene-2-0-?-D glucoside on neointima formation in a rat artery balloon injury model and its possible mechanisms." in: European journal of pharmacology, Vol. 698, Issue 1-3, pp. 370-8, (2013) (PubMed).

Jiang, Jin, Li, Zhang, Yang, Yang, Li, Yang, Ma: "Intermittent hypobaric hypoxia promotes atherosclerotic plaque instability in ApoE-deficient mice." in: High altitude medicine & biology, Vol. 14, Issue 2, pp. 175-80, (2013) (PubMed).

Hu, Wang, Zhao, Hu, Lu, Qin: "Overexpressed C-type natriuretic peptide serves as an early compensatory response to counteract extracellular matrix remodeling in unilateral ureteral obstruction rats." in: Molecular biology reports, Vol. 40, Issue 2, pp. 1429-41, (2013) (PubMed).

Shan, Zhou, He, Feng, Chen, Zhong: "Expression of both matrix metalloproteinase-2 and its tissue inhibitor-2 in tunica media of radial artery in uremic patients." in: Renal failure, Vol. 35, Issue 1, pp. 37-42, (2013) (PubMed).

Jin, Jiang, Yang, Zhang, Yang, Zhang, Li, Yang, Ma: "Acipimox attenuates atherosclerosis and enhances plaque stability in ApoE-deficient mice fed a palmitate-rich diet." in: Biochemical and biophysical research communications, Vol. 428, Issue 1, pp. 86-92, (2012) (PubMed).

Qiu, Zhou, Wang, Yang, Liu, Xu, Qi, Ding, Guo: "Synthetic gelatinases inhibitor attenuates electromagnetic pulse-induced blood-brain barrier disruption by inhibiting gelatinases-mediated ZO-1 degradation in rats." in: Toxicology, Vol. 285, Issue 1-2, pp. 31-8, (2011) (PubMed).

Fan, Zhao, Fu, Chen, Sun: "Norcantharidin inhibits growth of human gallbladder carcinoma xenografted tumors in nude mice by inducing apoptosis and blocking the cell cycle in vivo." in: Hepatobiliary & pancreatic diseases international : HBPD INT, Vol. 9, Issue 4, pp. 414-22, (2011) (PubMed).

Details zu TIMP2

Target: TIMP2 (Metalloproteinase Inhibitor 2 (TIMP2))

Andere Bezeichnung: TIMP2 (TIMP2 Produkte)

Synonyme: CSC-21K antikoerper, DDC8 antikoerper, timp2l antikoerper, zgc:65967 antikoerper, zgc:85799 antikoerper, D11Bwg1104e antikoerper, Timp-2 antikoerper, TIMP-2 antikoerper, etID32613.12 antikoerper, fa96h09 antikoerper, timp2 antikoerper, wu:fa96h09 antikoerper, zgc:136726 antikoerper, TIMP metallopeptidase inhibitor 2 antikoerper, TIMP metallopeptidase inhibitor 2b antikoerper, tissue inhibitor of metalloproteinase 2 antikoerper, TIMP metallopeptidase inhibitor 2a antikoerper, TIMP metallopeptidase inhibitor 2 L homeolog antikoerper, TIMP2 antikoerper, timp2b antikoerper, Timp2 antikoerper, timp2a antikoerper, timp2.L antikoerper

Hintergrund: TIMP metallopeptidase inhibitor 2, a tissue inhibitor of metalloproteinases, also known as TIMP2, is a human gene, thought to be a metastasis suppressor. This gene is a member of the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory role against metalloproteinases, the encoded protein has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. As a result, the encoded protein may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix.

Synonyms: CSC 21K antibody|CSC-21K antibody|CSC21K antibody|Metalloproteinase inhibitor 2 antibody|Metalloproteinase inhibitor 2 precursor antibody|TIMP 2 antibody|TIMP metallopeptidase inhibitor 2 antibody|TIMP-2 antibody|TIMP2 antibody|TIMP2_HUMAN antibody|Tissue Inhibitor of Metalloproteinase 2 antibody|Tissue inhibitor of metalloproteinases 2 antibody

UniProt: P16035

Pathways: cAMP Metabolic Process