PTGS2 Antikörper (C-Term)

Produktnummer ABIN3044296

Produktdetails anti-PTGS2 Antikörper

Target: PTGS2 (Prostaglandin-Endoperoxide Synthase 2 (Prostaglandin G/H Synthase and Cyclooxygenase) (PTGS2))

Bindungsspezifität: AA 589-604, C-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PTGS2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Verwendungszweck: Rabbit IgG polyclonal antibody for Prostaglandin G/H synthase 2(PTGS2) detection. Tested with WB, IHC-P, IHC-F in Human.

Sequenz: DDINPTVLLK ERSTEL

Kreuzreaktivität (Details): No cross reactivity with other proteins.

Produktmerkmale: Rabbit IgG polyclonal antibody for Prostaglandin G/H synthase 2(PTGS2) detection. Tested with WB, IHC-P, IHC-F in Human.
Gene Name: prostaglandin-endoperoxide synthase 2(prostaglandin G/H synthase and cyclooxygenase)
Protein Name: Prostaglandin G/H synthase 2

Aufreinigung: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human COX2(589-604aa DDINPTVLLKERSTEL).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human
IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
IHC-F: Concentration: 0.5-1 μg/mL, Tested Species: Human
Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.

Kommentare:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P) and IHC(F).

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

Konservierungsmittel: Thimerosal (Merthiolate), Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Haltbarkeit: 12 months

Referenzen für anti-PTGS2 Antikörper (ABIN3044296)

Li, Zhou, Wei, Chen, Geng, Zheng, Chai, Li, Jiang: "miR-144 and targets, c-fos and cyclooxygenase-2 (COX2), modulate synthesis of PGE2 in the amnion during pregnancy and labor." in: Scientific reports, Vol. 6, pp. 27914, (2018) (PubMed).

Wang, Yuan, Wang, Yang, Chen, Liu, Song, Feng, Tan, Jia: "Anti-inflammatory Effects of Phyllanthus emblica L on Benzopyrene-Induced Precancerous Lung Lesion by Regulating the IL-1β/miR-101/Lin28B Signaling Pathway." in: Integrative cancer therapies, Vol. 16, Issue 4, pp. 505-515, (2018) (PubMed).

Wang, Duan, Wu, Min, Huang, Luo, He: "Effect of cyclooxygenase‑2 inhibition on the development of post‑traumatic stress disorder in rats." in: Molecular medicine reports, Vol. 17, Issue 4, pp. 4925-4932, (2018) (PubMed).

Sun, Xue, Xue, Ren, Wu, Wang: "Acetylpuerarin protects against OGD-induced cell injury in BV2 microglia by inhibiting HMGB1 release." in: Die Pharmazie, Vol. 73, Issue 2, pp. 92-97, (2018) (PubMed).

Liu, Jia, Chong, Jiang, Yang, Li, Ma, Sun, Zhou: "Effects of oral cimetidine on the reproductive system of male rats." in: Experimental and therapeutic medicine, Vol. 15, Issue 6, pp. 4643-4650, (2018) (PubMed).

Ahmadieh, Nourinia, Hafezi-Moghadam, Sabbaghi, Nakao, Zandi, Yaseri, Tofighi, Akbarian: "Intravitreal injection of a Rho-kinase inhibitor (fasudil) combined with bevacizumab versus bevacizumab monotherapy for diabetic macular oedema: a pilot randomised clinical trial." in: The British journal of ophthalmology, (2018) (PubMed).

Zhang, Zhang, Yu, Du, Liu, Liu, An, Wang, Song, Li, Cao: "Effects of interferon tau on endometrial epithelial cells in caprine in vitro." in: Gene expression patterns : GEP, Vol. 25-26, pp. 142-148, (2017) (PubMed).

Alsaegh, Miyashita, Taniguchi, Zhu: "Odontogenic epithelial proliferation is correlated with COX-2 expression in dentigerous cyst and ameloblastoma." in: Experimental and therapeutic medicine, Vol. 13, Issue 1, pp. 247-253, (2017) (PubMed).

Sun, Yang, Zhang, Zhao: "Esculentoside A ameliorates cecal ligation and puncture-induced acute kidney injury in rats." in: Experimental animals, (2017) (PubMed).

Jiang, Tian, Tang, Ou, Xu et al.: "Granulocyte Macrophage-Colony Stimulating Factor (GM-CSF) Downregulates the Expression of Protumor Factors Cyclooxygenase-2 and Inducible Nitric Oxide Synthase in a GM-CSF Receptor-Independent Manner ..." in: Mediators of inflammation, Vol. 2015, pp. 601604, (2016) (PubMed).

Lin, Huang, Shen, Yiming: "MicroRNA-101 regulates the viability and invasion of cervical cancer cells." in: International journal of clinical and experimental pathology, Vol. 8, Issue 9, pp. 10148-55, (2016) (PubMed).

Shen, Chen, Zhang, Du, Bai, Zhang, Jiang, Li, Wang, Zhu: "MicroRNA-27b Regulates Mitochondria Biogenesis in Myocytes." in: PLoS ONE, Vol. 11, Issue 2, pp. e0148532, (2016) (PubMed).

Zhao, Zhao, Wang, Li, Zhang: "Glycyrrhizic Acid Attenuates Sepsis-Induced Acute Kidney Injury by Inhibiting NF-κB Signaling Pathway." in: Evidence-based complementary and alternative medicine : eCAM, Vol. 2016, pp. 8219287, (2016) (PubMed).

Alsaegh, Miyashita, Zhu: "Expression of human papillomavirus is correlated with Ki-67 and COX-2 expressions in keratocystic odontogenic tumor." in: Pathology oncology research : POR, Vol. 21, Issue 1, pp. 65-71, (2015) (PubMed).

Zhen, Zong, Gao, Cao, Jiang, Chen, Wang, Sun, Peng, Bai, Li: "Preparation and characterization of a novel aspirin derivative with anti-thrombotic and gastric mucosal protection properties." in: PLoS ONE, Vol. 9, Issue 6, pp. e98513, (2015) (PubMed).

Liu, Yan, Li, Yin, Sun, Kou, Ye, Ferns, Liu, Liu: "Reduced expression of SOX7 in ovarian cancer: a novel tumor suppressor through the Wnt/?-catenin signaling pathway." in: Journal of ovarian research, Vol. 7, pp. 87, (2014) (PubMed).

Wang, Yang, Cui, Chen, Jiang: "Anti-inflammatory and anti-nociceptive activities of methanol extract from aerial part of Phlomis younghusbandii Mukerjee." in: PLoS ONE, Vol. 9, Issue 3, pp. e89149, (2014) (PubMed).

Zhang, Xu, Xu, Qin: "?-Ecdysterone suppresses interleukin-1?-induced apoptosis and inflammation in rat chondrocytes via inhibition of NF-?B signaling pathway." in: Drug development research, Vol. 75, Issue 3, pp. 195-201, (2014) (PubMed).

Li, Chen, Lv, Dong, Zhang, Tu, Yang, Zhang, Song, Xu, Zou: "Influence of exercise on bone remodeling-related hormones and cytokines in ovariectomized rats: a model of postmenopausal osteoporosis." in: PLoS ONE, Vol. 9, Issue 11, pp. e112845, (2014) (PubMed).

Cao, Zhang, Xie, Jiang, Ji, Gao: "Chemokine CXCL1 enhances inflammatory pain and increases NMDA receptor activity and COX-2 expression in spinal cord neurons via activation of CXCR2." in: Experimental neurology, Vol. 261, pp. 328-36, (2014) (PubMed).

Details zu PTGS2

Target: PTGS2 (Prostaglandin-Endoperoxide Synthase 2 (Prostaglandin G/H Synthase and Cyclooxygenase) (PTGS2))

Andere Bezeichnung: PTGS2 (PTGS2 Produkte)

Synonyme: COX-2 antikoerper, COX2 antikoerper, GRIPGHS antikoerper, PGG/HS antikoerper, PGHS-2 antikoerper, PHS-2 antikoerper, hCox-2 antikoerper, Cox-2 antikoerper, Pghs2 antikoerper, TIS10 antikoerper, Cox2 antikoerper, cox-2 antikoerper, CEF147 antikoerper, PGHS2 antikoerper, PHSII antikoerper, cox2 antikoerper, gripghs antikoerper, pgg/hs antikoerper, pghs-2 antikoerper, phs-2 antikoerper, PTGS2 antikoerper, hcox-2 antikoerper, fj02a10 antikoerper, ptgs2 antikoerper, unp1239 antikoerper, wu:fj02a10 antikoerper, zCOX-2 antikoerper, si:dkey-97o5.6 antikoerper, prostaglandin-endoperoxide synthase 2 antikoerper, prostaglandin G/H synthase 2 antikoerper, prostaglandin-endoperoxide synthase 2S homeolog antikoerper, prostaglandin-endoperoxide synthase 2a antikoerper, prostaglandin-endoperoxide synthase 2b antikoerper, PTGS2 antikoerper, Ptgs2 antikoerper, LOC100136456 antikoerper, ptgs2.S antikoerper, ptgs2 antikoerper, ptgs2a antikoerper, ptgs2b antikoerper

Hintergrund: Cyclooxygenase(Cox) is the key enzyme in conversion of arachidonic acid to PGs, and two isoforms, Cox-1 and Cox-2, have been identified. Cox-2 gene encodes an inducible prostaglandin synthase enzyme that is overexpressed in adenocarcinomas and other tumors. Deletion of the murine Cox-2 gene in Min mice reduced the incidence of intestinal tumors, suggesting that it is required for tumorigenesis. This gene is localized to sites associated with retinal blood vessels, and plays an important role in blood vessel formation in the retina. And the glucocorticoid receptor suppression of COX-2 is also crucial for curtailing lethal immune activation, and suggest new therapeutic approaches for regulation of T-cell-mediated inflammatory diseases.

Synonyms: COX 2 antibody|COX-2 antibody|COX2 antibody|Cyclooxygenase 2 antibody|Cyclooxygenase 2b antibody|Cyclooxygenase antibody|Cyclooxygenase-2 antibody|Cyclooxygenase2 antibody|EC 1.14.99.1 antibody|fj02a10 antibody|Glucocorticoid-regulated inflammatory cyclooxygenase antibody|Glucocorticoid-regulated inflammatory Prostaglandin G/H synthase antibody|GRIPGHS antibody|hCox 2 antibody|Macrophage activation-associated marker protein P71/73 antibody|OTTHUMP00000033524 antibody|PES-2 antibody|PGG/HS antibody|PGH synthase 2 antibody|PGH2_HUMAN antibody|PGHS 2 antibody|PGHS-2 antibody|PGHS2 antibody|PHS 2 antibody|PHS II antibody|PHS2 antibody|Prostaglandin endoperoxide synthase 2(prostaglandin G/H synthase and cyclooxygenase) antibody|Prostaglandin endoperoxide synthase 2 antibody|Prostaglandin G/H synthase 2 antibody|Prostaglandin G/H synthase 2 precursor antibody|Prostaglandin G/H synthase and cyclooxygenase antibody|Prostaglandin G/H synthase antibody|Prostaglandin H2 synthase 2 antibody|prostaglandin-endoperoxide synthase 2(prostaglandin G/H synthase and cyclooxygenase) antibody|Prostaglandin-endoperoxide synthase 2 antibody|PTGS2 antibody|ptgs2a antibody|TIS10 antibody|TIS10 protein antibody|unp1239 antibody|wu:fj02a10 antibody

UniProt: P35354

Pathways: Brown Fat Cell Differentiation, Positive Regulation of fat Cell Differentiation