ABCB11 Antikörper (C-Term)

Produktnummer ABIN3043733

Produktdetails anti-ABCB11 Antikörper

Target: ABCB11 (ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 11 (ABCB11))

Bindungsspezifität: AA 1175-1199, C-Term

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ABCB11 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Verwendungszweck: Rabbit IgG polyclonal antibody for Bile salt export pump(ABCB11) detection. Tested with WB, IHC-P in Human,Mouse,Rat.

Sequenz: KYGDNTKEIP MERVIAAAKQ AQLHD

Kreuzreaktivität (Details): No cross reactivity with other proteins.

Produktmerkmale: Rabbit IgG polyclonal antibody for Bile salt export pump(ABCB11) detection. Tested with WB, IHC-P in Human,Mouse,Rat.
Gene Name: ATP-binding cassette, sub-family B (MDR/TAP), member 11
Protein Name: Bile salt export pump

Aufreinigung: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human ABCB11 (1175-1199aa KYGDNTKEIPMERVIAAAKQAQLHD), different from the related mouse and rat sequences by three amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Mouse, Rat, The detection limit for ABCB11 is approximately 0.1 ng/lane under reducing conditions.
IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Mouse, Rat, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
Notes: Tested Species: Species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users.

Kommentare:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Details zu ABCB11

Target: ABCB11 (ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 11 (ABCB11))

Andere Bezeichnung: ABCB11 (ABCB11 Produkte)

Synonyme: ABCB11 antikoerper, Bsep antikoerper, ABC16 antikoerper, BRIC2 antikoerper, BSEP antikoerper, PFIC-2 antikoerper, PFIC2 antikoerper, PGY4 antikoerper, SPGP antikoerper, Lith1 antikoerper, BSEP/SPGP antikoerper, Spgp antikoerper, ATP binding cassette subfamily B member 11 antikoerper, bile salt export pump antikoerper, ATP-binding cassette, sub-family B (MDR/TAP), member 11 antikoerper, ABCB11 antikoerper, LOC100489744 antikoerper, LOC100565276 antikoerper, EDI_111220 antikoerper, EDI_272930 antikoerper, abcb11 antikoerper, Abcb11 antikoerper

Hintergrund: Bile Salt Export Pump (BSEP) is a protein which in humans is encoded by the ABCB 11 gene. It is a member of the superfamily of ATP-binding cassette (ABC) transporters, also known as ABCB11. It is mapped to chromosome 2q24. The BSEP protein is mainly expressed in the liver. ABCB11 is a gene associated with progressive familial intrahepatic cholestasis type 2 (PFIC2) which caused by mutations in the ABCB11 gene will increases the risk of hepatocellular carcinoma in early life.

Synonyms: ABC member 16, MDR/TAP subfamily antibody|ABCB1 antibody|Abcb11 antibody|ABCBB_HUMAN antibody|ATP binding cassette sub family B (MDR/TAP) member 11 antibody|ATP binding cassette sub family B member 11 antibody|ATP-binding cassette sub-family B member 11 antibody|Bile salt export pump antibody|BRIC2 antibody|Bsep antibody|PGY4 antibody| progressive familial intrahepatic cholestasis 2 antibody|Sister of P glycoprotein antibody| Spgp antibody

Gen-ID: 8647

UniProt: O95342