MMP14 Antikörper (C-Term)

Produktnummer ABIN3043408

Produktdetails anti-MMP14 Antikörper

Target: MMP14 (Matrix Metallopeptidase 14 (Membrane-inserted) (MMP14))

Bindungsspezifität: AA 557-582, C-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MMP14 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Verwendungszweck: Rabbit IgG polyclonal antibody for Matrix metalloproteinase-14(MMP14) detection. Tested with WB in Human.

Sequenz: LAVFFFRRHG TPRRLLYCQR SLLDKV

Kreuzreaktivität (Details): No cross reactivity with other proteins.

Produktmerkmale: Rabbit IgG polyclonal antibody for Matrix metalloproteinase-14(MMP14) detection. Tested with WB in Human.
Gene Name: matrix metallopeptidase 14 (membrane-inserted)
Protein Name: Matrix metalloproteinase-14

Aufreinigung: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human MMP14 (557-582aa LAVFFFRRHGTPRRLLYCQRSLLDKV), different from the related mouse and rat sequences by one amino acid.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, The detection limit for MMP14 is approximately 0.25 ng/lane under reducing conditions.
Notes: Tested Species: Species with positive results.
Other applications have not been tested. Optimal dilutions should be determined by end users.

Kommentare:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Referenzen für anti-MMP14 Antikörper (ABIN3043408)

Tang, Pei, Yang, Wang, Wang, Gao, Li, Yang, Yang: "The inhibition of calpains ameliorates vascular restenosis through MMP2/TGF-β1 pathway." in: Scientific reports, Vol. 6, pp. 29975, (2018) (PubMed).

Liu, Li, Liang, Li, Jiang, Chu, Yang: "Hydrogen sulfide attenuates myocardial fibrosis in diabetic rats through the JAK/STAT signaling pathway." in: International journal of molecular medicine, Vol. 41, Issue 4, pp. 1867-1876, (2018) (PubMed).

Li, Li, Zeng, Liu, Yang: "H2S improves renal fibrosis in STZ-induced diabetic rats by ameliorating TGF-β1 expression." in: Renal failure, Vol. 39, Issue 1, pp. 265-272, (2017) (PubMed).

Shi, Wang, Zhang, Li, Guo, Li, Chen: "Effect of lentivirus-mediated uPA silencing on the proliferation and apoptosis of chondrocytes and the expression of MMPs." in: Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban, Vol. 35, Issue 1, pp. 111-6, (2015) (PubMed).

Xiao, Li, Yu, Xiao, Hu, Tang, Zeng, He, Zeng, Ye, Xu: "MicroRNA-10b promotes migration and invasion through KLF4 and HOXD10 in human bladder cancer." in: Oncology reports, Vol. 31, Issue 4, pp. 1832-8, (2014) (PubMed).

Zhou, Wu, Fu, Lv, Zhang: "Significance of semaphorin-3A and MMP-14 protein expression in non-small cell lung cancer." in: Oncology letters, Vol. 7, Issue 5, pp. 1395-1400, (2014) (PubMed).

Zhang, Sun, Zhang, Ge, Liu, Zhao, Lu, Fan: "Norcantharidin inhibits tumor growth and vasculogenic mimicry of human gallbladder carcinomas by suppression of the PI3-K/MMPs/Ln-5?2 signaling pathway." in: BMC cancer, Vol. 14, pp. 193, (2014) (PubMed).

Jiang, Jin, Li, Zhang, Yang, Yang, Li, Yang, Ma: "Intermittent hypobaric hypoxia promotes atherosclerotic plaque instability in ApoE-deficient mice." in: High altitude medicine & biology, Vol. 14, Issue 2, pp. 175-80, (2013) (PubMed).

Jin, Jiang, Yang, Zhang, Yang, Zhang, Li, Yang, Ma: "Acipimox attenuates atherosclerosis and enhances plaque stability in ApoE-deficient mice fed a palmitate-rich diet." in: Biochemical and biophysical research communications, Vol. 428, Issue 1, pp. 86-92, (2012) (PubMed).

Dong, Yu, Yang, Jiang, Zhang: "Expression of the reversion-inducing cysteine-rich protein with Kazal motifs and matrix metalloproteinase-14 in neuroblastoma and the role in tumour metastasis." in: International journal of experimental pathology, Vol. 91, Issue 4, pp. 368-73, (2010) (PubMed).

Details zu MMP14

Target: MMP14 (Matrix Metallopeptidase 14 (Membrane-inserted) (MMP14))

Andere Bezeichnung: MMP14 (MMP14 Produkte)

Synonyme: MMP1 antikoerper, MMP-14 antikoerper, MMP-X1 antikoerper, MT-MMP antikoerper, MT-MMP 1 antikoerper, MT1-MMP antikoerper, MT1MMP antikoerper, MTMMP1 antikoerper, mmp-x1 antikoerper, mt1-mmp antikoerper, mtmmp1 antikoerper, AI325305 antikoerper, MT-MMP-1 antikoerper, sabe antikoerper, Mt1-mmp antikoerper, MT-MMPbeta antikoerper, cb386 antikoerper, sb:cb386 antikoerper, wu:fb72b09 antikoerper, mmp14 antikoerper, matrix metallopeptidase 14 antikoerper, matrix metallopeptidase 14 (membrane-inserted) antikoerper, matrix metallopeptidase 14b (membrane-inserted) antikoerper, matrix metallopeptidase 14a (membrane-inserted) antikoerper, matrix metallopeptidase 14 L homeolog antikoerper, MMP14 antikoerper, mmp14 antikoerper, Mmp14 antikoerper, mmp14b antikoerper, mmp14a antikoerper, mmp14.L antikoerper

Hintergrund: Matrix metalloproteinase-14, also called MT-MMP 1, is an enzyme that in humans is encoded by the MMP14 gene. The protein encoded by this gene is a member of the membrane-type MMP subfamily. This gene is mapped to 14q11.2. Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. This gene may be involved in actin cytoskeleton reorganization by cleaving PTK7. It acts as a positive regulator of cell growth and migration via activation of MMP15.

Synonyms: Matrix metallopeptidase 14 (membrane inserted) antibody|Matrix metalloproteinase 14 antibody|Matrix metalloproteinase-14 antibody|Membrane type 1 matrix metalloproteinase antibody|Membrane type 1 metalloprotease antibody|Membrane type matrix metalloproteinase 1 antibody|Membrane-type matrix metalloproteinase 1 antibody|Membrane-type-1 matrix metalloproteinase antibody|MMP 14 antibody|MMP X1 antibody|MMP-14 antibody|MMP-X1 antibody|Mmp14 antibody|MMP14_HUMAN antibody|MMPX1 antibody|MT MMP 1 antibody|MT-MMP 1 antibody|MT1 MMP antibody|MT1-MMP antibody|MT1MMP antibody|MTMMP 1 antibody|MTMMP1 antibody

Gen-ID: 4323

UniProt: P50281

Pathways: Autophagie