Laminin Antikörper (N-Term)

Produktnummer ABIN3042862

Produktdetails anti-Laminin Antikörper

Target: Laminin (LAMA2) (Laminin, alpha 2 (LAMA2))

Bindungsspezifität: AA 152-170, N-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Laminin Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Verwendungszweck: Rabbit IgG polyclonal antibody for Laminin subunit alpha-2(LAMA2) detection. Tested with WB in Human,Mouse,Rat.

Sequenz: WILERSLDDV EYKPWQYHA

Kreuzreaktivität (Details): Predicted Cross Reactivity: mouse, rat
No cross reactivity with other proteins.
Predicted Cross Reactivity: Species predicted to be fit for the product based on sequence similarities.

Produktmerkmale: Rabbit IgG polyclonal antibody for Laminin subunit alpha-2(LAMA2) detection. Tested with WB in Human,Mouse,Rat.
Gene Name: laminin, alpha 2
Protein Name: Laminin subunit alpha-2

Aufreinigung: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the N-terminus of human Laminin 2 alpha(152-170aa WILERSLDDVEYKPWQYHA), identical to the related mouse sequence, and different from the related rat sequence by one amino acid.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Predicted Species: Mouse, Rat
Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities.
Other applications have not been tested. Optimal dilutions should be determined by end users.

Kommentare:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

Konservierungsmittel: Thimerosal (Merthiolate), Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Haltbarkeit: 12 months

Referenzen für anti-Laminin Antikörper (ABIN3042862)

Liu, Lu, Li, Wei, Li: "Engineering blood vessels through micropatterned co-culture of vascular endothelial and smooth muscle cells on bilayered electrospun fibrous mats with pDNA inoculation." in: Acta biomaterialia, Vol. 11, pp. 114-25, (2014) (PubMed).

Wu, Chen, Guo, He, Hu: "Effects of transforming growth factor-?2 on myocilin expression and secretion in human primary cultured trabecular meshwork cells." in: International journal of clinical and experimental pathology, Vol. 7, Issue 8, pp. 4827-36, (2014) (PubMed).

Gao, Zheng, Cai, Yao, Wang, Zhang, Wang: "Comparison of morphology and biocompatibility of acellular nerve scaffolds processed by different chemical methods." in: Journal of materials science. Materials in medicine, Vol. 25, Issue 5, pp. 1283-91, (2014) (PubMed).

Lin, Li, Su: "Three dimensional chitosan scaffolds influence the extra cellular matrix expression in Schwann cells." in: Materials science & engineering. C, Materials for biological applications, Vol. 42, pp. 474-8, (2014) (PubMed).

Chen, Wang, Liu, Fang, Tan, Zhou, Zhou, Lv: "Highly effective ex vivo gene manipulation to study kidney development using self-complementary adenoassociated viruses." in: TheScientificWorldJournal, Vol. 2014, pp. 682189, (2014) (PubMed).

Liang, Li, Wang, Wu, Cai, Cui, Yang, Ya: "Pulmonary endoderm, second heart field and the morphogenesis of distal outflow tract in mouse embryonic heart." in: Development, growth & differentiation, Vol. 56, Issue 4, pp. 276-92, (2014) (PubMed).

Chen, Wan, Xia, Guo, Wang, Liu, Li: "Promoted regeneration of mature blood vessels by electrospun fibers with loaded multiple pDNA-calcium phosphate nanoparticles." in: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fu?r Pharmazeutische Verfahrenstechnik e.V, Vol. 85, Issue 3 Pt A, pp. 699-710, (2013) (PubMed).

Xu, Zheng, He, Li, Zhang, Liang: "Puerarin, isolated from Pueraria lobata (Willd.), protects against hepatotoxicity via specific inhibition of the TGF-?1/Smad signaling pathway, thereby leading to anti-fibrotic effect." in: Phytomedicine : international journal of phytotherapy and phytopharmacology, Vol. 20, Issue 13, pp. 1172-9, (2013) (PubMed).

Cheng, Wang, Kang, Hu, Gao, Pan: "In vitro culture of tumour-derived hepatocytes in decellularised whole-liver biological scaffolds." in: Digestion, Vol. 87, Issue 3, pp. 189-95, (2013) (PubMed).

Guo, Xu, He, Liang, Duan, Li: "Anti-fibrotic effects of puerarin on CCl4-induced hepatic fibrosis in rats possibly through the regulation of PPAR-? expression and inhibition of PI3K/Akt pathway." in: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, Vol. 56, pp. 436-42, (2013) (PubMed).

Zhu, Xu, Yuan, Guo, Liu: "Transcriptome sequencing reveals differences between primary and secondary hair follicle-derived dermal papilla cells of the Cashmere goat (Capra hircus)." in: PLoS ONE, Vol. 8, Issue 9, pp. e76282, (2013) (PubMed).

He, Xia, Wang, Wei, Luo, Li: "Multiple release of polyplexes of plasmids VEGF and bFGF from electrospun fibrous scaffolds towards regeneration of mature blood vessels." in: Acta biomaterialia, Vol. 8, Issue 7, pp. 2659-69, (2012) (PubMed).

Chen, Mo, Sun, Huang, Zhang, Song: "Microplasmin degrades fibronectin and laminin at vitreoretinal interface and outer retina during enzymatic vitrectomy." in: Current eye research, Vol. 34, Issue 12, pp. 1057-64, (2009) (PubMed).

Details zu Laminin

Target: Laminin (LAMA2) (Laminin, alpha 2 (LAMA2))

Andere Bezeichnung: LAMA2 (LAMA2 Produkte)

Synonyme: LAMA2 antikoerper, LAMM antikoerper, 5830440B04 antikoerper, dy antikoerper, mKIAA4087 antikoerper, mer antikoerper, merosin antikoerper, laminin subunit alpha 2 antikoerper, laminin, alpha 2 antikoerper, laminin subunit alpha-2 antikoerper, LAMA2 antikoerper, lama2 antikoerper, LOC100460380 antikoerper, LOC100545053 antikoerper, Lama2 antikoerper

Hintergrund: Laminin, alpha-2, also known as LAMA2, is a protein that in humans is encoded by the LAMA2 gene. This gene is mapped to 6q22.33. Laminin, an extracellular protein, is a major component of the basement membrane. It is though to mediate the attachment, migration, and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. It is composed of three subunits, alpha, beta, and gamma, which are bound to each other by disulfide bonds into a cross-shaped molecule. This gene encodes the alpha 2 chain, which constitutes one of the subunits of laminin 2(merosin) and laminin 4(s-merosin). Mutations in this gene have been identified as the cause of congenital merosin-deficient muscular dystrophy. Two transcript variants encoding different proteins have been found for this gene.

Synonyms: LAMA 2 antibody|LAMA2 antibody|LAMA2_HUMAN antibody|Laminin alpha 2(merosin congenital muscular dystrophy) antibody|Laminin alpha 2 antibody|Laminin alpha 2 chain antibody|Laminin alpha 2 subunit antibody|Laminin M antibody|Laminin M chain antibody|Laminin subunit alpha-2 antibody|Laminin-12 subunit alpha antibody|Laminin-2 subunit alpha antibody|Laminin-4 subunit alpha antibody|LAMM antibody|Merosin heavy chain antibody

UniProt: P24043