TGFA Antikörper (C-Term)

Produktnummer ABIN3042615

Produktdetails anti-TGFA Antikörper

Target: TGFA (Transforming Growth Factor, alpha (TGFA))

Bindungsspezifität: AA 73-89, C-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TGFA Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Verwendungszweck: Rabbit IgG polyclonal antibody for Protransforming growth factor alpha(TGFA) detection. Tested with WB in Human.

Sequenz: CHSGYVGARC EHADLLA

Kreuzreaktivität (Details): No cross reactivity with other proteins.

Produktmerkmale: Rabbit IgG polyclonal antibody for Protransforming growth factor alpha(TGFA) detection. Tested with WB in Human.
Gene Name: transforming growth factor, alpha
Protein Name: Protransforming growth factor alpha

Aufreinigung: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human TGF alpha(73-89aa CHSGYVGARCEHADLLA), different from the related mouse and rat sequences by one amino acid.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Predicted Species: Mouse, Rat
Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities.
Other applications have not been tested. Optimal dilutions should be determined by end users.

Kommentare:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

Konservierungsmittel: Thimerosal (Merthiolate), Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Haltbarkeit: 12 months

Referenzen für anti-TGFA Antikörper (ABIN3042615)

Li, Pan, Qiu: "Imbalances of Th17 and Treg cells and their respective cytokines in COPD patients by disease stage." in: International journal of clinical and experimental medicine, Vol. 7, Issue 12, pp. 5324-9, (2015) (PubMed).

Ruan, Xu, Li, Zhu, Pang, Wang, Cai, He, Yao, Ruan, Xu, Pan: "Induced autologous stem cell transplantation for treatment of rabbit renal interstitial fibrosis." in: PLoS ONE, Vol. 8, Issue 12, pp. e83507, (2013) (PubMed).

Zhang, Chen, Qi, Wang, Xiao, Zhu: "Inhibition of calcium-calmodulin-dependent kinase II suppresses cardiac fibroblast proliferation and extracellular matrix secretion." in: Journal of cardiovascular pharmacology, Vol. 55, Issue 1, pp. 96-105, (2010) (PubMed).

Details zu TGFA

Target: TGFA (Transforming Growth Factor, alpha (TGFA))

Andere Bezeichnung: TGFA (TGFA Produkte)

Synonyme: TFGA antikoerper, LOC100009482 antikoerper, TGF alpha antikoerper, TGFA antikoerper, wa-1 antikoerper, wa1 antikoerper, RATTGFAA antikoerper, TGFAA antikoerper, NV15606 antikoerper, si:ch211-10e8.7 antikoerper, transforming growth factor alpha antikoerper, transforming growth factor alpha L homeolog antikoerper, transforming growth factor-alpha antikoerper, transforming growth factor, alpha antikoerper, TGFA antikoerper, TGF-A antikoerper, Tgfa antikoerper, tgfa.L antikoerper, LOC100121300 antikoerper, LOC100009150 antikoerper, tgfa antikoerper

Hintergrund: Transforming growth factor alpha(TGF-alpha) is upregulated in some human cancers. It is produced in macrophages, brain cells, and keratinocytes, and induces epithelial development. It is closely related to EGF, and can also bind to the EGF receptor with similar effects . TGFalpha stimulates neural cell proliferation in the adult injured brain. TGFalpha was cited in the 2001 NIH Stem Cell report to the U.S. Congress as promising evidence for the ability of adult stem cells to restore function in neurodegenerative disorders.

Synonyms: EGF like TGF antibody|EGF-like TGF antibody|ETGF antibody|TFGA antibody|TGF A antibody|TGF type 1 antibody|TGF-alpha antibody|TGFA antibody|TGFA_HUMAN antibody|Transforming growth factor alpha antibody|Transforming growth factor alpha precursor antibody|Wa1 antibody|Waved 1 antibody

UniProt: P01135

Pathways: NF-kappaB Signalweg, RTK Signalweg, EGFR Signaling Pathway