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CCL2 Antikörper (AA 24-99)

CCL2 Reaktivität: Human WB, ELISA Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN3042598
  • Target Alle CCL2 Antikörper anzeigen
    CCL2 (Chemokine (C-C Motif) Ligand 2 (CCL2))
    Bindungsspezifität
    • 24
    • 15
    • 13
    • 10
    • 8
    • 5
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 24-99
    Reaktivität
    • 105
    • 66
    • 63
    • 18
    • 18
    • 18
    • 16
    • 9
    • 3
    • 3
    • 2
    • 1
    • 1
    Human
    Wirt
    • 119
    • 62
    • 8
    • 7
    • 5
    • 3
    • 2
    • 2
    Kaninchen
    Klonalität
    • 135
    • 73
    Polyklonal
    Konjugat
    • 114
    • 39
    • 14
    • 7
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    Dieser CCL2 Antikörper ist unkonjugiert
    Applikation
    • 141
    • 75
    • 57
    • 29
    • 28
    • 25
    • 24
    • 18
    • 16
    • 15
    • 14
    • 13
    • 13
    • 13
    • 11
    • 6
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA
    Verwendungszweck
    Rabbit IgG polyclonal antibody for C-C motif chemokine 2(CCL2) detection. Tested with WB, ELISA in Human.
    Kreuzreaktivität (Details)
    No cross reactivity with other proteins.
    Produktmerkmale
    Rabbit IgG polyclonal antibody for C-C motif chemokine 2(CCL2) detection. Tested with WB, ELISA in Human.
    Gene Name: chemokine (C-C motif) ligand 2
    Protein Name: C-C motif chemokine 2
    Aufreinigung
    Immunogen affinity purified.
    Immunogen
    E. coli-derived human MCP-1 recombinant protein (Position: Q24-T99). Human MCP-1 shares 60.9% and 59.4% amino acid (aa) sequence identity with mouse and rat MCP-1, respectively.
    Isotyp
    IgG
    Top Product
    Discover our top product CCL2 Primärantikörper
  • Applikationshinweise
    WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human
    ELISA: Concentration: 0.1-0.5 μg/mL, Tested Species: Human

    Notes: Tested Species: Species with positive results.
    Other applications have not been tested. Optimal dilutions should be determined by end users.
    Kommentare

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    Konzentration
    500 μg/mL
    Buffer
    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    At -20°C for one year. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
  • Qian, Feng, Sun, Xiong, Ding, Han, Chen, Chen, Du, Wang: "Overexpression of Salusin-α Inhibits Vascular Intimal Hyperplasia in an Atherosclerotic Rabbit Model." in: BioMed research international, Vol. 2018, pp. 8973986, (2019) (PubMed).

    Xie, Li, Pi, Wu, Zeng, Zuo, Zha: "[Down-regulation of p38 MAPK and collagen by 1, 25-(OH)2-VD3 in rat models of diabetic nephropathy]." in: Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology, Vol. 32, Issue 7, pp. 931-5, (2017) (PubMed).

    Li, Lu, Sun, Zuo, Wang, Yan: "Inhibition of endoplasmic reticulum stress signaling pathway: A new mechanism of statins to suppress the development of abdominal aortic aneurysm." in: PLoS ONE, Vol. 12, Issue 4, pp. e0174821, (2017) (PubMed).

    Wu, Chang, Ren, Hu, Li, Liu: "Bindarit reduces the incidence of acute aortic dissection complicated lung injury via modulating NF-κB pathway." in: Experimental and therapeutic medicine, Vol. 14, Issue 3, pp. 2613-2618, (2017) (PubMed).

    Sun, Zhang, Zhao, Zhen, Huang, Wang, He, Liu, Xu, Yang, Qu, Ma, Zhang, Zhang, Hu: "Attenuation of atherosclerotic lesions in diabetic apolipoprotein E-deficient mice using gene silencing of macrophage migration inhibitory factor." in: Journal of cellular and molecular medicine, Vol. 19, Issue 4, pp. 836-49, (2016) (PubMed).

    Huang, Li, Niu, Xiao, Pu, Zheng, Qian: "Dynamic expressions of monocyte chemo attractant protein-1 and CC chamomile receptor 2 after balloon injury and their effects in intimal proliferation." in: Biomedical engineering online, Vol. 14, pp. 55, (2016) (PubMed).

    Sun, Fan, Wang, Lu, Zhang, Wu, Shan, Zheng: "Purple sweet potato color inhibits endothelial premature senescence by blocking the NLRP3 inflammasome." in: The Journal of nutritional biochemistry, Vol. 26, Issue 10, pp. 1029-40, (2015) (PubMed).

    Peng, Mao, Fu, Feng, Xu: "Comparison of biomarkers in rat renal ischemia-reperfusion injury." in: International journal of clinical and experimental medicine, Vol. 8, Issue 5, pp. 7577-84, (2015) (PubMed).

    Liu, Li, Qiu, He: "Expression and cellular distribution of TLR4, MyD88, and NF-?B in diabetic renal tubulointerstitial fibrosis, in vitro and in vivo." in: Diabetes research and clinical practice, Vol. 105, Issue 2, pp. 206-16, (2014) (PubMed).

    Tian, Lv, Yang, Zhang, Yu, Zhu, Xiao, Zhu: "Effects of vitamin D on renal fibrosis in diabetic nephropathy model rats." in: International journal of clinical and experimental pathology, Vol. 7, Issue 6, pp. 3028-37, (2014) (PubMed).

    Zhang, Wang, Ma, Liu, Zhang, Zhu: "Effect of herba centellae on the expression of HGF and MCP-1." in: Experimental and therapeutic medicine, Vol. 6, Issue 2, pp. 427-434, (2013) (PubMed).

    Sun, Bu, Liu, Yin, Zhou, Li, Xiao: "Therapeutic effects of human amniotic fluid-derived stem cells on renal interstitial fibrosis in a murine model of unilateral ureteral obstruction." in: PLoS ONE, Vol. 8, Issue 5, pp. e65042, (2013) (PubMed).

    Liu, Wang, Yang, Wang, Yang, Liu, Ye: "Calcium oxalate monohydrate crystals stimulate monocyte chemoattractant protein-1 and transforming growth factor ?1 expression in human renal epithelial cells." in: Molecular medicine reports, Vol. 5, Issue 5, pp. 1241-4, (2012) (PubMed).

    Lu, Zhu, Liang, Cui, Liu, Wu, Liang, Liu, Jiang, Liao, Xie, Zhou, Wu, Yuan, Liao: "Apelin-APJ induces ICAM-1, VCAM-1 and MCP-1 expression via NF-?B/JNK signal pathway in human umbilical vein endothelial cells." in: Amino acids, Vol. 43, Issue 5, pp. 2125-36, (2012) (PubMed).

    Zhang, Li, Li, Zhao, Su, Zhang, Zhang, Miao: "Lipopolysaccharide activated phosphatidylcholine-specific phospholipase C and induced IL-8 and MCP-1 production in vascular endothelial cells." in: Journal of cellular physiology, Vol. 226, Issue 6, pp. 1694-701, (2011) (PubMed).

    Xu, Feng, Wang, Zhu, Lin, Lou, Xiang, He, Zheng, Tang, Zuo: "Phytoestrogen calycosin-7-O-?-D-glucopyranoside ameliorates advanced glycation end products-induced HUVEC damage." in: Journal of cellular biochemistry, Vol. 112, Issue 10, pp. 2953-65, (2011) (PubMed).

    Ji, Gao, Cai, Lu, Hu, Wang, Cheng, Gu, Wan, Zhang, Cao: "Immunological regulation of Chinese herb Guizhi Fuling Capsule on rat endometriosis model." in: Journal of ethnopharmacology, Vol. 134, Issue 3, pp. 624-9, (2011) (PubMed).

    Li, Wang, Yang, Zhang, Han, Wang: "Fluoxetine inhibited extracellular matrix of pulmonary artery and inflammation of lungs in monocrotaline-treated rats." in: Acta pharmacologica Sinica, Vol. 32, Issue 2, pp. 217-22, (2011) (PubMed).

    He, Liang, Hou, Guo, Xie, Zhang: "Ethanol extraction of Picrorhiza scrophulariiflora prevents renal injury in experimental diabetes via anti-inflammation action." in: The Journal of endocrinology, Vol. 200, Issue 3, pp. 347-55, (2009) (PubMed).

    Li, Hou, Zhang, Chen, Liu, Feng, Liu, Shan, Wang, Zhou, Tian, Xie: "Advanced oxidation protein products accelerate renal fibrosis in a remnant kidney model." in: Journal of the American Society of Nephrology : JASN, Vol. 18, Issue 2, pp. 528-38, (2007) (PubMed).

  • Target
    CCL2 (Chemokine (C-C Motif) Ligand 2 (CCL2))
    Andere Bezeichnung
    CCL2 (CCL2 Produkte)
    Synonyme
    GDCF-2 antikoerper, HC11 antikoerper, HSMCR30 antikoerper, MCAF antikoerper, MCP-1 antikoerper, MCP1 antikoerper, SCYA2 antikoerper, SMC-CF antikoerper, AI323594 antikoerper, JE antikoerper, Scya2 antikoerper, Sigje antikoerper, MCP-1A antikoerper, MCP1A antikoerper, C-C motif chemokine ligand 2 antikoerper, chemokine (C-C motif) ligand 2 antikoerper, C-C motif chemokine 2 antikoerper, CCL2 antikoerper, Ccl2 antikoerper, LOC101120093 antikoerper
    Hintergrund
    Monocyte chemoattractant protein-1 (MCP-1), a member of the chemokine (chemotactic cytokine) family, is a potent monocyte agonist that is upregulated by oxidized lipids. MCP-1 is also known as CCL2, SCYA2, MCAF. MCAF is a member of family of factors involved in immune and inflammatory responses. The amino acid sequence deduced from the nucleotide sequence reveals the primary structure of the MCAF precursor to be composed of a putative signal peptide sequence of 23 amino acid residues and a mature MCAF sequence of 76 amino acid residues. MCP-1 plays a unique and crucial role in the initiation of atherosclerosis and may provide a new therapeutic target in this disorder. Human MCP-1 is a 8.7KDa non-glycoprotein, consisting of 99 amino acids in precursor form and 76 amino acids in mature form.

    Synonyms: C-C motif chemokine 2 antibody|CCL 2 antibody|CCL2 antibody|CCL2_HUMAN antibody|Chemokine (C C motif) ligand 2 antibody|Chemokine C C motif ligand 2 antibody|Chemokine CC Motif Ligand 2 antibody|GDCF 2 antibody|GDCF 2 HC11 antibody|GDCF-2 antibody|GDCF2 antibody|HC11 antibody|HSMCR30 antibody|HSMCR30 antibody|JE antibody|MCAF antibody|MCP 1 antibody|MCP-1 antibody|MCP1 antibody|MGC9434 antibody| Monocyte chemoattractant protein 1 antibody|Monocyte chemotactic and activating factor antibody|Monocyte chemotactic and activating factor antibody|Monocyte chemotactic protein 1 antibody|Monocyte secretory protein JE antibody|SCYA2 antibody|Small inducible cytokine A2 (monocyte chemotactic protein 1, homologous to mouse Sig je) antibody|Small inducible cytokine A2 antibody|Small inducible cytokine subfamily A (Cys Cys), member 2 antibody|Small inducible cytokine subfamily A Cys Cys member 2 antibody|Small-inducible cytokine A2 antibody|SMC CF antibody|SMC-CF antibody|SMCCF antibody
    Gen-ID
    6347
    UniProt
    P13500
    Pathways
    Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, ER-Nucleus Signaling, Unfolded Protein Response, Phosphorylierungen bei SARS-CoV-2 Infektion
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