PTGS1 Antikörper (AA 318-599)

Produktnummer ABIN3042528

Produktdetails anti-PTGS1 Antikörper

Target: PTGS1 (Prostaglandin-Endoperoxide Synthase 1 (Prostaglandin G/H Synthase and Cyclooxygenase) (PTGS1))

Bindungsspezifität: AA 318-599

Reaktivität: Human, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PTGS1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Verwendungszweck: Rabbit IgG polyclonal antibody for Prostaglandin G/H synthase 1(PTGS1) detection. Tested with WB, IHC-P in Human,Rat.

Marke: Picoband™

Kreuzreaktivität (Details): No cross reactivity with other proteins.

Produktmerkmale: Rabbit IgG polyclonal antibody for Prostaglandin G/H synthase 1(PTGS1) detection. Tested with WB, IHC-P in Human,Rat.
Gene Name: prostaglandin-endoperoxide synthase 1
Protein Name: Prostaglandin G/H synthase 1

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human COX1 recombinant protein (Position: E318-L599). Human COX1 shares 90% and 89% amino acid (aa) sequence identity with mouse and ratCOX1, respectively.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Rat
IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Rat, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
Notes: Tested Species: Species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users.

Kommentare:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Referenzen für anti-PTGS1 Antikörper (ABIN3042528)

Ahmadieh, Nourinia, Hafezi-Moghadam, Sabbaghi, Nakao, Zandi, Yaseri, Tofighi, Akbarian: "Intravitreal injection of a Rho-kinase inhibitor (fasudil) combined with bevacizumab versus bevacizumab monotherapy for diabetic macular oedema: a pilot randomised clinical trial." in: The British journal of ophthalmology, (2018) (PubMed).

Zhen, Zong, Gao, Cao, Jiang, Chen, Wang, Sun, Peng, Bai, Li: "Preparation and characterization of a novel aspirin derivative with anti-thrombotic and gastric mucosal protection properties." in: PLoS ONE, Vol. 9, Issue 6, pp. e98513, (2015) (PubMed).

Duan, Que, Lv, Li, Yin, Zhang: "Tolerance of neurite outgrowth to Rho kinase inhibitors decreased by cyclooxygenase-2 inhibitor." in: Neural regeneration research, Vol. 7, Issue 34, pp. 2705-12, (2014) (PubMed).

Details zu PTGS1

Target: PTGS1 (Prostaglandin-Endoperoxide Synthase 1 (Prostaglandin G/H Synthase and Cyclooxygenase) (PTGS1))

Andere Bezeichnung: PTGS1 (PTGS1 Produkte)

Synonyme: COX-1 antikoerper, cox-1 antikoerper, PTGS1 antikoerper, Ptgs1 antikoerper, COX1 antikoerper, Cox-1 antikoerper, Cox-3 antikoerper, PGHS-1 antikoerper, PHS 1 antikoerper, Pghs1 antikoerper, Cox1 antikoerper, Cox3 antikoerper, cox1 antikoerper, zCOX-1 antikoerper, COX3 antikoerper, PCOX1 antikoerper, PES-1 antikoerper, PGG/HS antikoerper, PGHS1 antikoerper, PHS1 antikoerper, PTGHS antikoerper, COX-3 antikoerper, prostaglandin-endoperoxide synthase 1 antikoerper, cyclooxygenase-1 antikoerper, prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) antikoerper, prostaglandin-endoperoxide synthase 1 S homeolog antikoerper, PTGS1 antikoerper, cox-1 antikoerper, Ptgs1 antikoerper, ptgs1 antikoerper, ptgs1.S antikoerper

Hintergrund: Cyclooxygenase 1(COX1), also known as Prostaglandin-endoperoxide synthase (PTGS1) or mitochondrial cytochrome c oxidase subunit 1, is the key enzyme in prostaglandin biosynthesis. The gene was approximately 40 kb long, with 11 protein-coding exons. There were 599 amino acid residues with a calculated molecular mass of approximately 68 kD. By analysis of a human/hamster somatic hybrid DNA panel, it was demonstrated that the PTGS1 gene maps to chromosome 9. Human prostaglandin endoperoxide synthase exhibited 91 % amino acid identity with the sheep enzyme. Prostaglandin synthase 1 gene disruption in mice reduces arachidonic acid-induced inflammation and indomethacin-induced gastric ulceration.

Synonyms: COX 1 antibody|COX 3 antibody|COX-1 antibody|COX1 antibody|COX3 antibody|Cyclooxygenase 1 antibody|Cyclooxygenase 3, included antibody|Cyclooxygenase-1 antibody|Cyclooxygenase1 antibody|EC 1.14.99.1 antibody|Partial COX1 proteins, included antibody|PCOX 1 antibody|PCOX1 antibody|PGG/HS antibody|PGH synthase 1 antibody|PGH1_HUMAN antibody|PGHS 1 antibody|PGHS-1 antibody|PGHS1 antibody|PHS 1 antibody|PHS1 antibody|Prostaglandin endoperoxide synthase 1 antibody|Prostaglandin G/H synthase 1 antibody|Prostaglandin G/H synthase and cyclooxygenase antibody|Prostaglandin H Synthase 1 antibody|Prostaglandin H2 synthase 1 antibody|Prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) antibody|Prostaglandin-endoperoxide synthase 1 antibody|PTGHS antibody|PTGS 1 antibody|PTGS1 antibody

UniProt: P23219