GFRA1 Antikörper (AA 25-227)

Produktnummer ABIN3042422

Produktdetails anti-GFRA1 Antikörper

Target: GFRA1 (GDNF Family Receptor alpha 1 (GFRA1))

Bindungsspezifität: AA 25-227

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GFRA1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Verwendungszweck: Rabbit IgG polyclonal antibody for GDNF family receptor alpha-1(GFRA1) detection. Tested with WB, IHC-P in Human.

Kreuzreaktivität (Details): No cross reactivity with other proteins.

Produktmerkmale: Rabbit IgG polyclonal antibody for GDNF family receptor alpha-1(GFRA1) detection. Tested with WB, IHC-P in Human.
Gene Name: GDNF family receptor alpha 1
Protein Name: GDNF family receptor alpha-1

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human GFRA1 recombinant protein (Position: D25-Q227). Human GFRA1 shares 97% amino acid (aa) sequence identity with both mouse and rat GFRA1.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, The detection limit for GFRA1 is approximately 0.2 ng/lane under reducing conditions.
IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
Notes: Tested Species: Species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users.

Kommentare:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Details zu GFRA1

Target: GFRA1 (GDNF Family Receptor alpha 1 (GFRA1))

Andere Bezeichnung: GFRA1 (GFRA1 Produkte)

Synonyme: gdnfr antikoerper, ret1l antikoerper, retl1 antikoerper, trnr1 antikoerper, gdnfra antikoerper, MGC122616 antikoerper, gfr-alpha-1 antikoerper, GDNFR antikoerper, GDNFRA antikoerper, GFR-ALPHA-1 antikoerper, RET1L antikoerper, RETL1 antikoerper, TRNR1 antikoerper, GDNFRALPHA antikoerper, GFRA1 antikoerper, AU042498 antikoerper, gfralpha1a antikoerper, zgc:110129 antikoerper, GDNF family receptor alpha 1 antikoerper, glial cell line derived neurotrophic factor family receptor alpha 1 antikoerper, gdnf family receptor alpha 1a antikoerper, gfra1 antikoerper, GFRA1 antikoerper, Gfra1 antikoerper, gfra1a antikoerper

Hintergrund: GDNF family receptor alpha-1 (GFRα1), also known as the GDNF receptor or GFRA1, is a protein that in humans is encoded by the GFRA1 gene. It is mapped to chromosome 10q25.3. The protein encoded by this gene is a member of the GDNF receptor family. GFRA1 is released by neuronal cells, Schwann cells, and injured sciatic nerve. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This gene is also a candidate gene for Hirschsprung disease. Soluble GFRA1 mediates robust recruitment of RET to lipid rafts via a mechanism requiring the RET tyrosine kinase.

Synonyms: GDNF Family Receptor Alpha 1 antibody|GDNF R antibody|GDNF RA antibody|GDNF receptor alpha antibody|GDNFR alpha 1 antibody|GDNFR alpha antibody|GDNFR antibody|GDNFRA antibody|GDNFRalpha antibody|GFR alpha 1 antibody|GFR alpha1 antibody|GFR-ALPHA-1 antibody|GFRA 1 antibody|GFRA1 antibody|GFRalpha1 antibody|Glial Cell Line DErived Neurotrophic Factor Receptor Alpha antibody|Glial cell line-derived neurotrophic factor receptor alpha antibody|GPI linked anchor protein antibody|GPI-linked anchor protein antibody|MGC23045 antibody|PI linked cell surface accessory protein antibody|RET 1L antibody|RET ligand 1 antibody|RET1L antibody|RETL 1 antibody|RETL1 antibody|TGF beta related neurotrophic factor receptor 1 antibody|TGF-beta related neurotrophic factor receptor 1 antibody|TRNR 1 antibody|TRNR1 antibody

Gen-ID: 14585

UniProt: P56159