Produktbeschreibung » anti-Oazin (Antizyme inhibitor 1) Antikörper

Antigen	Oazin (Antizyme inhibitor 1)
Immunogen	Affinity-purified Antizyme inhibitor from rat liver
Reaktivität	Human, Mouse (Murine), Rat (Rattus)
Klonalität	Monoklonal
Format	Ion exchange chromatography
Isotyp	IgG3 »Passende Sekundärantikörper
Beschreibung	ODC (ornithine decarboxylase) is a key enzyme in polyamine biosynthesis pathway. The degradation of ODC catalyzed by the 26S proteasome is accelerated by antizyme, an ODC inhibitory protein induced poliamine. Antizyme inhibitor 1 (AZI) specifically binds to antizyme with a higher affinity than that of ODC and thus can release active ODC from inactive ODC-antizyme complex. AZI consists of about 450 amino acids and 50 kDa protein. AZI is highly homologous to ODC but retains no enzymatic activity. AZI is a short-living protein that undergoes proteasomal degradation and the degradation is inhibited by interaction with antizyme. AZI is induced in cells and tissues following growth stimulation, is elevated in some tumors. AZI overexpression leads to increased rates of cell proliferation in the rat carcinoma cells and mouse fibroblasts and this effect appears to be partially independent of the ability of AZI to interact with antizyme. It has been also reported that antizyme and AZI localize to centrosome and may play an important role in the regulation of centrosome homeostasis and oncogenesis.
Klon	HI-12
Wirt	Mouse

Anwendungen » anti-Oazin (Antizyme inhibitor 1) Antikörper

Applikation	Western Blotting (WB), Immunocytochemistry (ICC) » Hier finden Sie 2 Protokolle zu den gelisteten Anwendungen
Applikationshinweise	WB: 0.25 ug/mL. ICC 30 ug/mL
Konzentration	0.25 mg/ml
Reinigung	Ion exchange chromatography
Buffer	PBS [containing 2 % Block Ace as a stabilizer, 0.1 %Proclin as a bacteriostat]
Lagerung	Store below
Forschungsgebiet	Enzyme, Metabolismus, Proteasome
Beschränkungen	Nur für Forschungszwecke einsetzbar

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	Antigen:	Oazin (Antizyme inhibitor 1)
	Klonalität:	Monoklonal (HI-12)
	Applikation:	Western Blotting (WB), Immunocytochemistry (ICC)
	Reaktivität:	Human, Mouse (Murine), Rat (Rattus)
	Wirt:	Mouse
	Menge:	50 ug (0.25 mg/ml)
	Preis:	739,04 € (Zzgl. Versandkosten und MWSt)
	Bestellnummer:	ABIN303592
	Verfügbarkeit:	Lieferbar innerhalb von 5 Werktagen