NOTCH2 Antikörper (cleaved, Intracellular, N-Term)

Produktnummer ABIN303375

Der Kaninchen Polyklonal anti-NOTCH2 Antikörper (ABIN303375) detektiert spezifisch NOTCH2 in IHC (p) und EIA. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für NOTCH2 Antikörper (cleaved, Intracellular, N-Term) (ABIN303375)

Target: NOTCH2 (Notch 2 (NOTCH2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NOTCH2 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Produktdetails anti-NOTCH2 Antikörper

Bindungsspezifität: cleaved, Intracellular, N-Term

Spezifität: This antibody recognises Notch Homolog 2 (NOTCH2).

Aufreinigung: Sterile filtration.

Immunogen: Synthetic Peptide corresponding to Amino acid residues of human Notch 2 located near the N-terminal sequence of the Cleaved N Intracellular Domain (NICD).

Anwendungsinformationen

Applikationshinweise: Immunohistochemistry on Paraffin Sections (1/500). ELISA.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 with 0.01 % (w/v) Sodium Azide as preservative.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid cycles of freezing and thawing.

Lagerung: -20 °C

Informationen zur Lagerung: Store vial at-20 °C prior to opening. Aliquot contents and freeze at-20 °C or below for extended storage. Centrifuge product if not completely clear after standing at room temperature.

Details zu NOTCH2

Target: NOTCH2 (Notch 2 (NOTCH2))

Andere Bezeichnung: NOTCH2

Hintergrund: Notch is synthesized in the endoplasmic reticulum as an inactive form which is proteolytically cleaved by a furin-like convertase (S1 cleavage) in the trans-golgi network before it reaches the plasma membrane to yield an active, ligand-accessible form. Cleavage results in a C-terminal fragment N(TM) and a N-terminal fragment N(EC). Following ligand binding, it is cleaved (S2 cleavage) by TNF-alpha converting enzyme (TACE) to yield a membrane-associated intermediate fragment called Notch extracellular truncation (NEXT). This fragment is then cleaved by presenilin-dependent gamma-secretase (S3 cleavage) to release the intracellular domain (NICD) from the membrane.Synonyms: Neurogenic locus notch homolog protein 2, Notch 2, hN2

Gen-ID: 4853

NCBI Accession: NP_001186930

UniProt: Q04721

Pathways: Notch Signalweg, Stem Cell Maintenance