FANCA Antikörper (AA 995-1009)

Produktnummer ABIN303358

Produktdetails anti-FANCA Antikörper

Target: FANCA (Fanconi Anemia Group A Protein (FANCA))

Bindungsspezifität: AA 995-1009

Reaktivität: Human, Affe

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FANCA Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Spezifität: This antibody detects Fanconi Anemia Group A Gene (FANCA).

Aufreinigung: Immunoaffinity Chromatography.

Immunogen: Synthetic peptide corresponding to Amino acids 995-1009 of human FANCA protein.

Anwendungsinformationen

Applikationshinweise: Immunohistochemistry on Paraffin Sections (2.5 μg/mL). Immunofluorescence. Western Blot (1/500-1/3000). ELISA (1/15000-1/60000).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 with 0.01 % (w/v) Sodium Azide as preservative.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid cycles of freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or at-20 °C for longer. Dilute only prior to immediate use.

Details zu FANCA

Target: FANCA (Fanconi Anemia Group A Protein (FANCA))

Andere Bezeichnung: FANCA (FANCA Produkte)

Synonyme: FA antikoerper, FA-H antikoerper, FA1 antikoerper, FAA antikoerper, FACA antikoerper, FAH antikoerper, FANCH antikoerper, AW208693 antikoerper, Fanconi anemia complementation group A antikoerper, Fanconi anemia, complementation group A antikoerper, FANCA antikoerper, Fanca antikoerper

Hintergrund: FANCA (also called Protein FACA or Fanconi anemia group A protein) is involved in DNA repair, perhaps specifically with post-replication repair or a cell cycle checkpoint function. FANCA may also be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, and FANCL. The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity, they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group A. Alternative splicing results in multiple transcript variants encoding different isoforms. Variant 1 (isoform a) encodes the longest transcript. Variant 2 (isoform b) contains an alternate exon, which results in an early stop codon, compared to variant 1. Isoform b has a shorter C-terminus when compared to isoform a. Mutations in this gene are the most common cause of Fanconi anemia.Synonyms: FAA, FACA, FANCH, Fanconi anemia group A protein

Gen-ID: 2175

NCBI Accession: NP_000126

UniProt: O15360

Pathways: DNA Reparatur