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LAMP2 Antikörper (Center)

LAMP2 Reaktivität: Human, Maus WB, IF, IHC (p) Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN303278
  • Target Alle LAMP2 Antikörper anzeigen
    LAMP2 (Lysosomal-Associated Membrane Protein 2 (LAMP2))
    Bindungsspezifität
    • 16
    • 13
    • 11
    • 8
    • 8
    • 7
    • 6
    • 6
    • 6
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Center
    Reaktivität
    • 113
    • 78
    • 36
    • 16
    • 3
    • 3
    • 2
    • 1
    Human, Maus
    Wirt
    • 86
    • 42
    • 34
    Kaninchen
    Klonalität
    • 85
    • 76
    Polyklonal
    Konjugat
    • 60
    • 20
    • 20
    • 15
    • 11
    • 8
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser LAMP2 Antikörper ist unkonjugiert
    Applikation
    • 115
    • 56
    • 53
    • 37
    • 34
    • 29
    • 28
    • 15
    • 13
    • 13
    • 12
    • 7
    • 5
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Spezifität
    This antibody detects CD107b.
    Kreuzreaktivität (Details)
    Species reactivity (expected):Mouse.
    Species reactivity (tested):Human.
    Aufreinigung
    Immunoaffinity Chromatography
    Immunogen
    Synthetic Peptide corresponding to 17 amino acid peptide from near the center of human LAMP-2
    Top Product
    Discover our top product LAMP2 Primärantikörper
  • Applikationshinweise
    Immunohistochemistry on Paraffin Sections (5 μg/mL). Immunocytochemistry.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    1.0 mg/mL
    Buffer
    PBS containing 0.02 % Sodium Azide as preservative
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer. Dilute only prior to immediate use.
  • Target
    LAMP2 (Lysosomal-Associated Membrane Protein 2 (LAMP2))
    Andere Bezeichnung
    CD107b / LAMP2 (LAMP2 Produkte)
    Synonyme
    CD107b antikoerper, LAMP-2 antikoerper, LAMPB antikoerper, LGP110 antikoerper, Lamp-2 antikoerper, Lamp-2a antikoerper, Lamp-2b antikoerper, Lamp-2c antikoerper, Mac3 antikoerper, cd107b antikoerper, lamp-2 antikoerper, lampb antikoerper, LAMP2 antikoerper, lamp2 antikoerper, DKFZp459J126 antikoerper, LGP-B antikoerper, sb:cb587 antikoerper, wu:fb14a06 antikoerper, zgc:103532 antikoerper, lysosomal associated membrane protein 2 antikoerper, lysosomal-associated membrane protein 2 antikoerper, lysosomal-associated membrane protein 2 S homeolog antikoerper, lysosomal membrane glycoprotein 2 antikoerper, LAMP2 antikoerper, Lamp2 antikoerper, lamp2.S antikoerper, lamp2 antikoerper
    Hintergrund
    Lysosme associated membrane proteins, or LAMP1 and LAMP2, are major constituents of the lysosomal membrane. The two have closely related structures, with 37 % sequence homology (2). They are both transmembrane glycoproteins that are localized primarily in lysosomes and late endosomes. Newly synthesized molecules are mostly transported from the trans-Golgi network directly to endosomes and then to lysosomes. A second pathway involves the lamps being delivered from the Golgi to the cell surface, and then along the endocytic pathway to the lysosomes. A minor pathway involves transport via the plasma membrane (3). LAMP2 has also been detected at the plasma membrane of cells, as well as in cells that secrete lysosomal hydrolases. A study in the developmental expresses patterns of membrane LAMP2 transcripts indicate a possible involvement of this protein in cell-cell or cellextracellular matrix interaction, and appear to reflect tissue and cell type specific roles of lysosomes during morphogenesis (4). Upon stimulation, a rapid translocation of intracellular LAMPs to the cell membrane is dependent on a carboxylterminal tyrosine based motif (YXXI) (5). This stimulation has also been shown to have an associated release of histamine, leukotriene C 9$) and prostaglandin D 9@), which shows that LAMP1 and LAMP2 are activation markers for normal mast cells (5). They have also been linked to the inflammatory response in that they promote adhesion of human peripheral blood mononuclear cells (PBMC) to vascular endothelium, and therefore possibly the adhesion of PBMC to the site of inflammation (6). LAMP2 has also been shown to be critical for autophagy, in conversion of early autophagic vacuoles to vacuoles which rapidly degrade their content (7).Synonyms: LAMP-2, LAMP-2C, LAMPB, Lysosome-associated membrane glycoprotein 2
    Gen-ID
    3920
    NCBI Accession
    NP_002285
    UniProt
    P13473
    Pathways
    Autophagie
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