CLEC4E Antikörper (C-Term)

Produktnummer ABIN3024557

Produktdetails anti-CLEC4E Antikörper

Target: CLEC4E (C-Type Lectin Domain Family 4, Member E (CLEC4E))

Bindungsspezifität: C-Term

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CLEC4E Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Aufreinigung: Protein A affinity chromatography

Immunogen: A recombinant protein fragment from the C-terminal portion of human CLEC4E was used as the immunogen for this antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Provided assay concentrations are suggestions only, CLEC4E antibody titration may be required for optimal results.\. Western blot: 2-5 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: 0.5 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the CLEC4E antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Details zu CLEC4E

Target: CLEC4E (C-Type Lectin Domain Family 4, Member E (CLEC4E))

Andere Bezeichnung: CLEC4E (CLEC4E Produkte)

Synonyme: CLECSF9 antikoerper, MINCLE antikoerper, C86253 antikoerper, Clecsf9 antikoerper, Mincle antikoerper, CLEC4E antikoerper, C-type lectin domain family 4 member E antikoerper, C-type lectin domain family 4, member e antikoerper, C-type lectin domain family 4, member E antikoerper, CLEC4E antikoerper, Clec4e antikoerper, LOC611538 antikoerper

Hintergrund: CLEC4 is a member of the C-type lectin family of proteins that plays a role in inflammatory and immune response. CLEC4E, also called Mincle (Macrophage-inducible C-type lectin), is found on the surface of activated macrophages and phagocytes. It is a receptor for both non-self (fungi and mycobacteria), and self (damaged cells) ligands. Dead cells release SAP130 (Sin3A-Associated Protein, 130  kDa), a small nuclear ribonucleoprotein component. CLEC4E senses this and interacts with the ITAM-containing adaptor protein FcRgamma, and via Syk and CARD9 signaling, activates the production of inflammatory cytokines such as TNFa, MIP-2 and IL-6.

Gen-ID: 26253