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CD8a Molecule (CD8A) Antikörper (Biotin)

Antigen	CD8a Molecule (CD8A)
Synonyme	CD8, MAL, p32, Leu2, Ly-2, Ly-B, Ly-35, Lyt-2, BB154331, MGC136643, zgc:136643, cd8, LOC100136450
Klonalität	Monoklonal (MEM-87)
Wirt	Alternativen Maus Maus (430), Ratte (139), Kaninchen (92)
Reaktivität	Alternativen Human Human (356), Maus (143), Ratte (Rattus) (68), Huhn (33), Katze (27), Affe (23), Schwein (18), Hund (16), Rind (Kuh) (13), Schaf (13), Kaninchen (10), Pferd (8), Meerschweinchen (6), Pute (5), Ziege (4), Vogel (1), Ente (1)
Konjugat	Alternativen Biotin FITC (108), Biotin (66), PE (61), APC (23), Cy5 (12), RPE (12), PE,Cy7 (8), PE,Cy5 (5), SPRD (5), Alexa Fluor 488 (4), HRP (4), PE,Cy5.5 (4), APC,Cy7 (3), Alexa Flour 488 (3), Alexa Fluor 647 (3), Cy3 (3), Cy5,PE (3), Cy5.5 (3), Cy7 (3), Gold (3), PE,Cy3 (3), Pacific Blue (3), RBITC (3), Alexa Fluor 350 (2), Alexa Fluor 555 (2), Alexa Fluor 700 (2), PE,Texas Red (TR) (2), PerCP (2), APC,Cy5.5 (1), Cy5.5,PE (1), Cy7,PE (1), DY647 (1), PE,DY590 (1), PE,DY647 (1), PE-Dyomics 590 (1), PE-Dyomics 647 (1), RPE,Cy5 (1), RPE,Cy5.5 (1), RPE,Cy7 (1)

Produktnummer	ABIN301999
Menge	0.1 mg (1 mg/ml)
Preis	230,00 € Zzgl. Versandkosten €20,00 und MWSt
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Verfügbarkeit	Lieferung in 3 bis 5 Werktagen

Produktbeschreibung
Anwendungen Alternativen zurück nach oben

Weitere Bezeichnung	CD8
Immunogen	Leukocytes of a patient suffering from LGL Type Leukemia.
Isotyp	IgG1
Klon	MEM-87
Beschreibung	The CD8 T cell coreceptor (monomer approx. 32-34 kDa) is expressed as alpha/betaheterodimer on majority of MHC I-restricted conventional T cells and thymocytes and asalpha/alpha homodimer on subsets of memory T cells, intraepithelial lymphocytes, NK cellsand dendritic cells. Regulation of CD8 beta level on T cell surface seems to be an importantmechanism to control their effector function. Assembly of CD8 alpha-beta but notalpha-alpha dimers is connected with formation or localization to the lipid rafts. Recruitingtriggered TCR complexes to these membrane microdomains as well as affinity of TCR toMHC I is modulated by CD8, thereby affecting the functional diversity of the TCR signaling.
Spezifität	The antibody MEM-87 recognizes CD8, a cell surface glycoprotein found on most cytotoxicT lymphocytes that mediates efficient cell-cell interactions within the immune system. CD8 isa disulfide-linked dimer and exists as a CD8 alpha/alpha homodimer or CD8 alpha/betaheterodimer (each monomer approx. 32-34 kDa).

Anwendungen
Alternativen zurück nach oben

Applikationshinweise	Biotinylated antibody is designed for indirect immunofluorescence analysis by FlowCytometry. Suggested working dilution is 5-10 µg/ml. Indicated dilution is recommended starting pointfor use of this product. Working concentrations should be determined by the investigator.
Konzentration	1 mg/ml
Buffer	Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4
Lagerung	Store at 2-8 o C. Do not use after expiration date stamped on vial label. For long-term storage aliquot and store at -20 o C. Avoid freeze/thaw cycles.
Forschungsgebiet	Immunologie, Adaptive Immunität, Hämopoetische Vorläufer, CD Antigene, Oberflächenrezeptoren der Immunzellen
Beschränkungen	Nur für Forschungszwecke einsetzbar

Alternativen
Anwendungen zurück nach oben

Alternativen zu Antigen "CD8a Molecule (CD8A)", Typ "Antikörper" finden

Wirte	Maus (430), Ratte (139), Kaninchen (92)
Reaktivitäten	Human (356), Maus (143), Ratte (Rattus) (68), Huhn (33), Katze (27), Affe (23), Schwein (18), Hund (16), Rind (Kuh) (13), Schaf (13), Kaninchen (10), Pferd (8), Meerschweinchen (6), Pute (5), Ziege (4), Vogel (1), Ente (1)
Applikationen	Durchflusszytometrie (FACS) (525), Immunhistochemie (Gefrierschnitte) (IHC (fro)) (196), Immunpräzipitation (IP) (121), Immunhistochemie (Paraffinschnitte) (IHC (p)) (66), Immunfluoreszenz (IF) (62), Western Blot (WB) (54), ELISA (33), Immunhistochemie (IHC) (22), Immunzytochemie (ICC) (16), Funktionale Studien (Func) (9), Blockierende Antikörper (Inhibition) (6), Zytotoxizitätstest (CyTox) (6), Enzyme Immunoassay (EIA) (6), Immunhistochemie (formalinfixierte Schnitte) (IHC (f)) (6), Immunoelectron Microscopy (IEM) (3), ELISA (Detektionsantikörper) (2), Dot Blot (Dot) (1), Radioimmunoassay (RIA) (1), To be determined by user (TBD) (1)
Konjugate	FITC (108), Biotin (66), PE (61), APC (23), Cy5 (12), RPE (12), PE,Cy7 (8), PE,Cy5 (5), SPRD (5), Alexa Fluor 488 (4), HRP (4), PE,Cy5.5 (4), APC,Cy7 (3), Alexa Flour 488 (3), Alexa Fluor 647 (3), Cy3 (3), Cy5,PE (3), Cy5.5 (3), Cy7 (3), Gold (3), PE,Cy3 (3), Pacific Blue (3), RBITC (3), Alexa Fluor 350 (2), Alexa Fluor 555 (2), Alexa Fluor 700 (2), PE,Texas Red (TR) (2), PerCP (2), APC,Cy5.5 (1), Cy5.5,PE (1), Cy7,PE (1), DY647 (1), PE,DY590 (1), PE,DY647 (1), PE-Dyomics 590 (1), PE-Dyomics 647 (1), RPE,Cy5 (1), RPE,Cy5.5 (1), RPE,Cy7 (1)
Epitope	C-Term (1), N-Term (1)