|
Antigen
|
Histone H1
|
|
Immunogen
|
Nuclei from myeloid leukemia biopsy cells
|
|
Reaktivität
|
Human
|
|
Klonalität
|
Monoklonal
|
|
Isotyp
|
IgG2a »Passende Sekundärantikörper
|
|
Beschreibung
|
Gene: Histone H1.
|
|
Klon
|
AE-4
|
|
Wirt
|
Mouse
|
|
Spezifität
|
Recognizes histone H1. The histone proteins serve as a structural scaffold for the organization of nuclear DNA into chromatin. In eukaryotic cells there are 4 core histone proteins, H2A, H2B, H3 and H4 that assemble to form an octamer round which the DNA is wrapped in a sequence dependant manner. The resulting complex is known as a nucleosome and is the basic subunit of chromatin. Histone H1 acts as a linker and binds to each nucleosome, and by self affinity, links these nucleosomes together resulting in the 30 nm chromatin fiber. In blots of rat brain homogenate a duplet is observed at 27-29 kD consistent with Histone H1. Speckled staining is observed in the nucleus of normal and malignant cells.
|