CD59(HRF20) Antikörper

Antigen: CD59(HRF20)

Klonalität: Monoklonal (YUK1)

Wirt: Maus

Reaktivität: Human

Applikation: Durchflusszytometrie (FACS), Immunpräzipitation (IP)

Produktnummer: ABIN290056

Produktbeschreibung

Immunogen: human cancer cel line

Format: Affinity-purified

Isotyp: IgG1 kappa  (Passende Sekundärantikörper)

Klon: YUK1

Beschreibung: CD59 (also known as HRF20: 20KDa-Homologous restriction factor) is an about 20 kDa glycoprotein and member of membrane-boundcomplement-regulatory protein (CRP), and prevents formation of the membrane attack complex (MAC) in the terminal stages of complementactivation. CRPs inhibit complement-mediated killing of host cells by host complement. It has been also showed that p53 regulates cellularresistance to complement lysis through enhanced expression of CD59.CRPs are often elevated in malignancy, and enable tumor cells to escape from complement-dependent cytotoxicity. Therefore, expression,overexpression, or loss of these molecules may function as markers of tumor progression and prognosis.This antibody is specific to human CD59 and will be useful for FCM, immunoprecipitation

Anwendungen

Applikationshinweise: WB Not tested. IHC Not tested. ICC Not tested. ELISA Not tested. FCM 5.0-10.0 ug/ml. Neutralization Not tested. IP 5.0-10.0 ug/ml

Konzentration: 0.25 mg/ml

Reinigung: Protein G

Buffer: PBS (containing 2% Block Ace as a stabilizer, 0.1% Proclin as a bacteriostat)

Lagerung: Store below -20

Beschränkungen: Nur für Forschungszwecke einsetzbar