Beta3-AR Antikörper

Antigen: Beta3-AR

Klonalität: Polyklonal

Wirt: Kaninchen

Reaktivität: Human

Applikation: Western Blot (WB)

Produktnummer: ABIN290046

Produktbeschreibung

Immunogen: Partial peptide of Human beta3-AR

Format: Affinity-purified

Beschreibung: The neurotransmitter/hormone adrenaline (epinephrine, adrenalin) plays a central role in the mammalianstress response, increasing heart rate, raising blood pressure, and increasing blood glucose levels upon enteringthe blood stream.Adrenaline is secreted primarily by the adrenal medulla. Adrenaline activates both alpha-adrenergic receptors and beta-adrenergic receptors. Three subtypes of beta adrenergic receptors are known, beta1, beta2, beta3, expressed primarily inheart, respiratory tissue, and adipose tissue, respectively. Beta3-receptors are particularly abundant in brown adipocytes and play important roles in lipolysis andtheremoregulation. (Ref.1, Ref.2) Recently this receptor has received attention from researchers intereseted in type 2diabetes mellitus and obesity. It is also being considered as a therapertic target for heart failure (Ref.3).

Anwendungen

Applikationshinweise: Working dilution For Western blotting: 5.0ug/ml

Konzentration: 0.25 mg/ml

Reinigung: This antibody was prepared from the serum of a rabbit immunized with a partial peptide representing the C-terminal domain of Human beta3-AR, and purified by peptide affinity chromatography.

Buffer: PBS (containing 2% Block Ace as a stabilizer, 0.1% Proclin as a bacteriostat)

Lagerung: Store below -20

Beschränkungen: Nur für Forschungszwecke einsetzbar

Bilder

Western blotting Sample: Extracted protein from mouse adipose tissue