Ectonucleotide Pyrophosphatase/phosphodiesterase 2 (ENPP2) Antikörper

Antigen: Ectonucleotide Pyrophosphatase/phosphodiesterase 2 (ENPP2)

Synonyme: ATX, NPP2, ATX-X, PDNP2, LysoPLD, FLJ26803, AUTOTAXIN, PD-IALPHA, Npps2, Pdnp2, PD-Ialpha, MGC93258, MGC63550, zgc:63550, ENPP2, MGC142749, MGC132047, DKFZp459E207

Klonalität: Polyklonal

Wirt: Kaninchen

Reaktivität: Ratte (Rattus)

Applikation: Western Blot (WB)

Produktnummer: ABIN290037

Produktbeschreibung

Weitere Bezeichnung: Autotaxin

Immunogen: Partial peptide of Autotaxin (N-Term)

Format: Affinity-purified

Beschreibung: Autotaxin, a member of the ENPP (Ectonucleotide pyrophospatase/phosphodiesterase) family ofectoenzymes, was originally identified as a motogen secreted by a melanoma cell line and subsequentlyreported to promote cell proliferation, cell motility, angiogenesis, and neurite retraction. Autotaxin haslysophospholipase D activity and appears to exert its effects by generation of the lipid mediatorlysophosphatidic acid (LPA) from lysophosphatidylcholine and sphingosine 1-phosphate (S1P) fromsphingosylphosphorylcholine (SPC) outside the cell.Autotaxin levels are significantly higher in cancerous tissues than in normal tissues suggesting that thisnovel extracellular protein may be involved in tumor progression.Two Autotaxin antibodies are available,KM105: Specifically reacts with a C-terminal fragment of AutotaxinKM106: Specifically reacts with an N-terminal fragment of Autotaxin

Anwendungen

Applikationshinweise: Working dilution For Western blotting:0.5ug/ml

Konzentration: 0.1 mg/ml

Reinigung: This antibody was established from the serum of a rabbit immunized with a peptiderepresenting the N-terminal domain of Autotaxin.Purified by peptide affinity chromatography.

Buffer: PBS (containing 2% Block Ace as a stabilizer, 0.1% Proclin as a bacteriostat)

Lagerung: Store below -20

Beschränkungen: Nur für Forschungszwecke einsetzbar

Bilder

Western blotting Sample: Conditioned medium from COS7 cells (1) Autotaxin-trasfected cells (2) Negative control cells. Preparation of antibodies and instruction:Masu M.Koike S.University of TsukubaGraduate School of Comprehensive Human Sciences