Transient Receptor Potential Cation Channel, Subfamily M, Member 8 (TRPM8) Antikörper

Antigen: Transient Receptor Potential Cation Channel, Subfamily M, Member 8 (TRPM8)

Synonyme: TRPP8, LTRPC6, MGC2849, CMR1, Trp-p8, LTrpC-6, TRPM8, trpp8, ltrpc6, trpm8b

Klonalität: Polyklonal

Wirt: Kaninchen

Reaktivität: Ratte (Rattus)

Applikation: Immunhistochemie (IHC)

Produktnummer: ABIN289994

Produktbeschreibung

Weitere Bezeichnung: TRPM8 (CMR1)

Immunogen: Partial peptide of Rat Cold / menthol receptor 1(TRPM8)

Format: Affinity-purified

Beschreibung: All mammalians including human being can detect the temperature by their own skin. Recently, severalmolecular mechanism has been proposed to explain physiological stimuli. For example capsaicin receptors,TRPV1 (VR-1) and TRPV2 (VRL-1), which are related with noxious stimuli were cloned and found thatthese molecules were activated by temperatures exceeding 43C and exceeding 50C. Jullus et al. and Patapoutian et al. found novel receptor, TRPM8 (cold and menthol-sensitive receptor 1 :CMR1), and reported to Nature and Cell in which they described that these molecules were activated in temperature range 8-28C. These findings might become driving force to investigate the mammalian peripheral nervous system. So that, in near future, the advantage of molecular physiology could account forthermal stimuli such as "Why human can distinguish between cold and warm", "Why the nervous activity accompanied by cold sensation does not always induce an unpleasant feelingor pain". This antibody is very useful for investigating TRPM8 (CMR1) expression pattern and analyzing the function.

Anwendungen

Applikationshinweise: Working dilution Immunohistochemistry : 2-5ug/ml

Konzentration: 0.25 mg/ml

Reinigung: This antibody was purified from rabbit serum by affinity chromatography.

Buffer: PBS (containing 2% Block Ace as a stabilizer, 0.1% Proclin as a bacteriostat)

Lagerung: Store below -20

Beschränkungen: Nur für Forschungszwecke einsetzbar

Bilder

Immunohistochemistry Sample: Rat dorsal root neuron(Positive: Green). Preparation of antibodies and instruction: Dr.Makoto Tominaga at Department of Physiology,Mie University School of Medicine