Seven in Absentia 2 (SIAH2) Antikörper

Antigen: Seven in Absentia 2 (SIAH2)

Klonalität: Polyklonal

Wirt: Kaninchen

Reaktivität: Human

Applikation: Western Blot (WB)

Produktnummer: ABIN289990

Produktbeschreibung

Weitere Bezeichnung: Siah 2

Immunogen: Partial peptide of Human Siah 2

Format: Affinity-purified

Beschreibung: The turnover of a protein is precisely under control in the cell. Particularly, the system of controlling protein degradation via the ubiquitin-proteosome pathway is involving in many kinds of process in the cell. The Drosophila Seven in absentina (Sina) gene product originally was identified as a protein that controls cell fate decisions during eye development. Its mammalian homolog, Siah1 and Siah2, have been describedthat they might involve in ubiquitin-mediated proteolysis of several proteins, as well as in growth arrest and p53-induced apoptosis. Siah2 is expressed in olfactory epithelium, retina, forebrain and proliferatingcartilage of developing bone by mRNA level.This antibody is very useful for identifying the function of the mammalian Siah2 in the cell.

Anwendungen

Applikationshinweise: Working dilution Western Blotting: 0.2ug/ml

Konzentration: 0.25 mg/ml

Reinigung: This antibody was purified from rabbit serum by affinity chromatography.

Buffer: PBS (containing 2% Block Ace as a stabilizer, 0.1% Proclin as a bacteriostat)

Lagerung: Store below -20

Beschränkungen: Nur für Forschungszwecke einsetzbar

Bilder

Western Blotting Sample: 293 cell lysate 1) control 2) Siah1 gene transgenic cell MG-132 protease inhibitor. Preparation of antibodies and instruction: Dr.Koki Moriyoshi at Department of Biological Sciences,Kyoto University Faculty of Medicine