Advanced Glycosylation End Product-Specific Receptor (AGER) Antikörper

Antigen: Advanced Glycosylation End Product-Specific Receptor (AGER)

Synonyme: RAGE, MGC22357, AGER, MGC140817

Klonalität: Polyklonal

Wirt: Kaninchen

Reaktivität: Human

Applikation: Western Blot (WB)

Produktnummer: ABIN289974

Produktbeschreibung

Weitere Bezeichnung: RAGE

Immunogen: Partial peptide of Human RAGE

Format: Affinity-purified

Beschreibung: RAGE is the receptor of AGEs, advanced glycation end products with 35,000 molecularweight and was cloned from bovine lung in 1992 ( David Stern et al.,). RAGE has been foundin several tissues such as monocytes, macrophages, endothelial cells, astocytes. The ligand ofRAGE is demonstrated not only AGEs but also anfoterin, EN-RAGE,N-carboxymethyllysine(CML),beta-amyloid and so on. The accumulation of AGEs-proteins invivo has been demonstrated in several disease, it is not clear whether AGEs-proteinsaccumulated in vivo is a direct cause of the disease or rather reflects its effect. Regarding this issue, AGEs-modified proteins are known to interact with several cells by the AGEs-receptors and induce several cellular phenomena. Recently, it has been discovered that RAGE isinvolved in pathophysiological function of diabetes and Alzheimer

Anwendungen

Konzentration: 0.25 mg/ml

Reinigung: This antibody was purified from rabbit serum by Protein G affinity chromatography.

Buffer: PBS (containing 2% Block Ace as a stabilizer, 0.1% Proclin as a bacteriostat)

Lagerung: Store below -20

Beschränkungen: Nur für Forschungszwecke einsetzbar

Bilder

Western blotting Sample: Cell lysates ofCHO-RAGE or A549 cells (5ug/lane). Preparation of antibodies and instruction: Prof. S Horiuch., Department of Biochemistry KumamotoUniversity School of Medicine