Organic Anion Transporter 3 (OAT3) Antikörper

Antigen: Organic Anion Transporter 3 (OAT3)

Synonyme: OAT3, MGC24086, Oat3, Roct, OCT3, MGC93369, SLC22A8

Klonalität: Polyklonal

Wirt: Kaninchen

Reaktivität: Ratte (Rattus)

Applikation: Immunhistochemie (IHC), Western Blot (WB)

Produktnummer: ABIN289970

Produktbeschreibung

Immunogen: Partial peptide of Rat Organic Anion Transporter 3 (OAT3)

Format: Affinity-purified

Beschreibung: To eliminate the drug, xenobiotics, a varirety of endogeneous substances, and their metabolites out of thebody, specific membrane proteins named transporters are required. There are two major pathways for theelimination, one of which is hepatic one through bile, and another is renal one to urine. The transporter fallinto various transport systems by the transportative substrate. In particular, oraganic ion transporter familyis comprised of organic anion transport family (OAT), oraganic cation transport family (OCT),OCTN/carnitine transport family, and OAT are multispecific organic anion transpoters, the substrates ofwhich include a lot of both endogeneous and exogeneous anions.Rat organic anion transporter 3 (OAT3) encodes a 536 amino acid residue protein, of which molecularweight is 130kDa. OAT3 is expressed in the kidney, liver, brain, and eye. OAT3 mediated the uptake oforganic anions, such as PAH (p-aminohippurate), ochratoxin A and estrone sulfate, cimetidine, andprostaglandin E2.This antidody has been proved to be useful for immunohistochemistry.

Anwendungen

Applikationshinweise: Working dilution For immunohistochemistry:2-5ug/ml

Konzentration: 0.1 mg/ml

Reinigung: This antibody was purified from rabbit serum immunized with synthesized C-end peptide of rat OAT3 by peptide affinity chromatography.

Buffer: PBS (containing 2% Block Ace as a stabilizer, 0.1% Proclin as a bacteriostat)

Lagerung: Store below -20

Forschungsgebiet: Ionenkanäle, Transporter

Beschränkungen: Nur für Forschungszwecke einsetzbar

Bilder

Rat Kidney (frozen section). Basal lamina side of renal tubule are positively stained.