Solute Carrier Family 7 (Cationic Amino Acid Transporter, Y+ System), Member 7 (Slc7a7) Antikörper

Antigen: Solute Carrier Family 7 (Cationic Amino Acid Transporter, Y+ System), Member 7 (Slc7a7)

Synonyme: TA1, 4F2LC, D0H16S474E, SLC7A5, JHI-21, LAT1, my+lat1, AI790233, y+LAT1, MGC78892, MGC123300, zgc:123300

Klonalität: Polyklonal

Wirt: Kaninchen

Reaktivität: Human

Applikation: Immunhistochemie (IHC)

Produktnummer: ABIN289962

Produktbeschreibung

Weitere Bezeichnung: L-type Amino Acid Transporter 1(LAT1)

Immunogen: Partial peptide of Human L-type Amino Acid Transporter 1(LAT1)

Format: Affinity-purified

Beschreibung: Mammalian amino acid transport system is consisted of large variety of transporters, with the reflection ofamino acid molecule variety, and is classfied into various transport systems by the transportative substrateselectivity and the Na+ dependence with the reflection of amino acid molecule variety.L-type amino acid transporter 1 (LAT1) is a predicted 12 membrane-spanning protein and is uniquebecause it requires an additional single membrane spanning protein, 4F2 heavy chain (4F2hc:CD98), for itsfunctional expression. L-type is Na+ -independent neutral amino acid transporter agency and essential forthe transporter of large neutral amino acid such as Leucine, Isoleucine, Varine through the plasmamembrane. LAT1 is, thus transporter responsible for the permeation of aromatic or branched-chain aminoacids and amino acid-related drugs such as L-DOPA. LAT has been proposed to be one of the majornutrient transport systems at the blood-brain barrier. Highly regulated nature and high level of expression intumor cell lines, LAT is thought to be up-regulated to support the high protein synthesis for cell glowth andcell activation.This antibody has been proved to be useful for the immunohistochemistry.

Anwendungen

Applikationshinweise: Working dilution for immunohistochemistry: 5-10ug/ml

Konzentration: 0.1 mg/ml

Reinigung: This antidody was purified from rabbit serum immunized with synthesized peptide ofC- end of human LAT1 and has been proved to be useful for the immunohistochemistry

Buffer: PBS (containing 2% Block Ace as a stabilizer, 0.1% Proclin as a bacteriostat)

Lagerung: Store below -20

Beschränkungen: Nur für Forschungszwecke einsetzbar

Bilder

4F2hc LAT Transporter Family Heterodimeric Complex