CML Antikörper

Antigen: CML

Klonalität: Monoklonal (CMS-10)

Wirt: Maus

Reaktivität: Alle Spezies

Applikation: Immunhistochemie (IHC), ELISA

Produktnummer: ABIN289943

Produktbeschreibung

Immunogen: CML-KLH

Format: Affinity-purified

Isotyp: IgG1  (Passende Sekundärantikörper)

Klon: CMS-10

Beschreibung: Reaction of protein amino groups with glucose leads, through the early products such as a Schiff base and Amadori rearrangement products, to the formation of advanced glycation end products (AGEs). Recent immunological studies using anti-AGEs antibody (6D12) demonstrated the presence of AGEs-modifiedproteins in several human tissues: human lens (nondiabetic and noncataractous), renal proximaltubules in patients with diabetic nephropathy and chronic renal failure, diabetic retina, peripheral nerves of diabetic neuropathy, atherosclerotic lesions of arterial walls, beta2-microglobulin forming amyloid fibrils in patients with hemodialysis-related amyloidosis, senileplaques of patients with Alzheimer

Anwendungen

Applikationshinweise: Working dilution for immunohistochemistry: 5-10ug/ml, for ELISA: 0.1-1.0ug/ml

Konzentration: 0.25 mg/ml

Reinigung: The splenic lymphocytes from BALB/c mouse, immunized with CML-KLH were fused to myeloma P3U1 cells. The cell line (CMS-10) with positive reaction wasgrown in ascitic fluid of BALB/c mouse, from which the antibody was purified byProtein G affinity chromatography.

Buffer: PBS (containing 2% Block Ace as a stabilizer, 0.1% Proclin as a bacteriostat)

Lagerung: Store below -20

Beschränkungen: Nur für Forschungszwecke einsetzbar