Fibrinogen Antikörper (FITC)

Details for Product anti-Fibrinogen Antibody No. ABIN2859190, Anbieter: Anmelden zum Anzeigen
Antigen
  • fib2
  • MGC53620
  • fibrinogen
  • sb:cb892
  • wu:fa55c12
  • wu:fb20e08
  • wu:fb59b03
  • wu:fi39d04
  • zgc:92117
  • fibrinogen alpha chain
  • fibrinogen gamma chain
  • fga
  • FGA
  • LOC698244
  • CpipJ_CPIJ010090
  • FGG
Reaktivität
Human, Schwein, Ratte (Rattus), Kaninchen
314
86
55
32
28
24
13
4
1
1
1
Wirt
Huhn
158
158
129
62
8
3
Klonalität
Polyklonal
Konjugat
Dieser Fibrinogen Antikörper ist konjugiert mit FITC
46
46
44
7
6
6
4
4
4
4
4
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
Applikation
Flow Cytometry (FACS)
332
257
54
54
52
42
40
38
35
33
28
26
20
19
15
9
7
6
4
3
2
2
2
1
1
1
1
1
1
1
1
1
Optionen
Hersteller
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Hersteller Produkt- Nr.
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Immunogen Purified, full length native fibrinogen Q9UE34
Isotyp IgY
Kreuzreaktivität (Details) Not reactive in: no confirmed exceptions from predicted reactivity known in the moment
Homologie bovine, mouse
Produktmerkmale Expected / apparent Molecular Weight of the Antigene: 24 kDa
Reinigung affinity purified
Hintergrund Fibrinogen is the main protein of blood coagulation system. It is a large protein and it consists of two identical subunits that contain three polypeptide chains: alpha, beta and gamma. All chains are connected with each other by a number of disulfide bonds. Fibrinopeptides A (1 to 16 amino acids) and B (1 to 17 amino acids) are released by thrombin from the N-terminal parts of alpha and beta chains, respectively. In this way fibrinogen is converted into fibrin, which by means of polymerization forms a fibrin clot. Fibrinogen clotting underlies pathogenesis of MI, thromboembolism and thromboses of arteries and veins, since fibrin is the main substrate for thrombus formation. Fibrinogen activation is also involved in pathogenesis of inflammation, tumor growth and many other diseases. The normal fibrinogen concentration in plasma is about 3 mg/ml. The elevated level of fibrinogen in patient's blood is regarded as an independent risk factor for cardiovascular diseases. An increase in blood fibrinogen concentration was shown to be a strong predictor of coronary heart disease (Sonel et al. 2000, Rapold et al. 1989).
Molekulargewicht 24 kDa
UniProt Q9UE34
Forschungsgebiet Cardiovascular, Atherosclerosis, Extracellular Matrix, Coagulation
Applikationshinweise 1: 10 (FC)
Kommentare

the antibodies have been shown to react with activated human, porcine, rat and rabbit platelets

Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 0.2 mg/mL
Buffer 0.15 M sodium chloride 0.02 M sodium phosphate 0.1 % sodium azide pH 7.2
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung Please, remember to spin tubes briefly prior to opening them to avoid any losses that might occur from liquid material adhering to the cap or sides of the tubes.
Make aliquots to avoid repreated freeze-thaw cycles and working with a stock.
Lagerung 4 °C
Informationen zur Lagerung store at 4°C, make aliquots to avoid working with a stock. Please, remember to spin tubes briefly prior to opening them to avoid any losses that might occur from liquid material adhering to the cap or sides of the tubes.
Allgemeine Veröffentlichungen Terada, Mori, Okazaki, Satake, Tadokoro: "Effects of riboflavin and ultraviolet light treatment on platelet thrombus formation on collagen via integrin ?IIb?3 activation." in: Transfusion, Vol. 54, Issue 7, pp. 1808-16, 2014 (PubMed).

Schmidt, Zündorf, Grüger, Brandenburg, Reiners, Zinserling, Witte, Schnitzler: "Phenotyping of Staphylococcus aureus reveals a new virulent ST398 lineage." in: Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, Vol. 19, Issue 3, pp. 279-85, 2013 (PubMed).

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