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CBFA2T2 Antikörper (C-Term)

CBFA2T2 Reaktivität: Human WB, IF, ICC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN2856638
  • Target Alle CBFA2T2 Antikörper anzeigen
    CBFA2T2 (Core-binding Factor, Runt Domain, alpha Subunit 2, Translocated To, 2 (CBFA2T2))
    Bindungsspezifität
    • 15
    • 10
    • 8
    • 7
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reaktivität
    • 56
    • 10
    • 8
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    Human
    Wirt
    • 49
    • 6
    • 3
    • 1
    Kaninchen
    Klonalität
    • 54
    • 5
    Polyklonal
    Konjugat
    • 35
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser CBFA2T2 Antikörper ist unkonjugiert
    Applikation
    • 57
    • 22
    • 13
    • 13
    • 8
    • 5
    • 5
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC)
    Kreuzreaktivität
    Maus, Huhn, Ratte (Rattus)
    Kreuzreaktivität (Details)
    Mouse (95 %), Chicken (80 %), Rat (95 %)
    Produktmerkmale
    Rabbit polyclonal antibody to CBFA2T2 (core-binding factor, runt domain, alpha subunit 2, translocated to, 2)
    MTGR1 antibody [C1C3]
    Aufreinigung
    Purified by antigen-affinity chromatography.
    Immunogen
    Recombinant protein encompassing a sequence within the C-terminus region of human MTGR1. The exact sequence is proprietary.
    Isotyp
    IgG
    Top Product
    Discover our top product CBFA2T2 Primärantikörper
  • Applikationshinweise
    Suggested dilution Reference ICC/IF 1:100-1:1000* Western blot 1:500-1:3000* Not tested in other applications. *Optimal dilutions/concentrations should be determined by the researcher.Suggested dilutionReferenceICC/IF1:100-1:1000* Western blot1:500-1:3000*
    Kommentare

    Positive Control: 293T , A431 , H1299 , HeLa , HepG2 , Molt-4 , Raji

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    0.1M Tris, 0.1M Glycine, 10 % Glycerol ( pH 7). 0.01 % Thimerosal was added as a preservative.
    Konservierungsmittel
    Thimerosal (Merthiolate)
    Vorsichtsmaßnahmen
    This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
  • Target
    CBFA2T2 (Core-binding Factor, Runt Domain, alpha Subunit 2, Translocated To, 2 (CBFA2T2))
    Andere Bezeichnung
    CBFA2T2 (CBFA2T2 Produkte)
    Synonyme
    MTGR1 antikoerper, A430091M07 antikoerper, C330013D05Rik antikoerper, Cbfa2t2h antikoerper, EHT antikoerper, ZMYND3 antikoerper, p85 antikoerper, XETOR antikoerper, cbfa2t2-a antikoerper, CBFA2/RUNX1 translocation partner 2 antikoerper, core-binding factor, runt domain, alpha subunit 2, translocated to, 2 (human) antikoerper, CBFA2/RUNX1 translocation partner 2 L homeolog antikoerper, Cbfa2t2 antikoerper, CBFA2T2 antikoerper, cbfa2t2.L antikoerper
    Hintergrund
    In acute myeloid leukemia, especially in the M2 subtype, the t(8,21)(q22,q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 (AML1) gene fused to the 3'-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript variants are thought to exist for this gene, but the full-length natures of only three have been described.

    Cellular Localization: Nucleus
    Molekulargewicht
    67 kDa
    Gen-ID
    9139
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