MAPK8IP1 Antikörper (Mitogen-Activated Protein Kinase 8 Interacting Protein 1) (Center)

Details for Product anti-MAPK8IP1 Antibody No. ABIN2854806, Anbieter: Anmelden zum Anzeigen
Antigen
  • IB1
  • JIP-1
  • Jip1
  • Prkm8ip
  • Skip
  • mjip-2a
  • JIP1
  • Jip-1
  • Mapk8ip
  • PRKM8IP
  • mitogen-activated protein kinase 8 interacting protein 1
  • MAPK8IP1
  • LOC100344706
  • Mapk8ip1
Epitop
Center
18
7
5
5
3
2
2
1
1
1
1
1
Reaktivität
Human, Maus
66
45
40
Wirt
Kaninchen
69
2
1
Klonalität
Polyklonal
Konjugat
Dieser MAPK8IP1 Antikörper ist unkonjugiert
3
3
3
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Applikation
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
56
31
17
13
8
7
4
3
2
2
1
Optionen
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Immunogen Recombinant protein encompassing a sequence within the center region of human JIP1. The exact sequence is proprietary.
Isotyp IgG
Produktmerkmale Rabbit Polyclonal antibody to JIP1 (mitogen-activated protein kinase 8 interacting protein 1)
JIP1 antibody
Reinigung Purified by antigen-affinity chromatography.
Andere Bezeichnung JIP1 (MAPK8IP1 Antibody Abstract)
Hintergrund The protein encoded by this gene is a regulator of the pancreatic beta-cell function. It is highly similar to JIP-1, a mouse protein known to be a regulator of c-Jun amino-terminal kinase (Mapk8). This protein has been shown to prevent MAPK8 mediated activation of transcription factors, and decrease IL-1 beta and MAP kinase kinase 1 (MEKK1) induced apoptosis in pancreatic beta cells. This protein also functions as a DNA-binding transactivator of the glucose transporter GLUT2. RE1-silencing transcription factor (REST) is reported to repress the expression of this gene in insulin-secreting beta cells. This gene is found to be mutated in a type 2 diabetes family, and thus is thought to be a susceptibility gene for type 2 diabetes.

Cellular Localization: Cytoplasm (By similarity) , Cytoplasm , perinuclear region (By similarity) , Nucleus (By similarity)
Molekulargewicht 78 kDa
Gen-ID 9479
Applikationshinweise Suggested dilution Reference IHC (Formalin-fixed paraffin-embedded sections) 1:100-1:1000* Western blot 1:500-1:3000* Not tested in other applications. *Optimal dilutions/concentrations should be determined by the researcher.Suggested dilutionReferenceIHC (Formalin-fixed paraffin-embedded sections)1:100-1:1000* Western blot1:500-1:3000*
Kommentare

Positive Control: HepG2

Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 mg/mL
Buffer 0.1M Tris, 0.1M Glycine, 10 % Glycerol ( pH 7). 0.01 % Thimerosal was added as a preservative.
Konservierungsmittel Thimerosal (Merthiolate)
Vorsichtsmaßnahmen This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
Bilder des Herstellers
Western Blotting (WB) image for anti-MAPK8IP1 Antikörper (Mitogen-Activated Protein Kinase 8 Interacting Protein 1) (Center) (ABIN2854806) WB Image Sample(30 ug whole cell lysate) A:Hep G2 , 7.5% SDS PAGE antibody diluted at...
Immunohistochemistry (IHC) image for anti-MAPK8IP1 Antikörper (Mitogen-Activated Protein Kinase 8 Interacting Protein 1) (Center) (ABIN2854806) IHC-P Image JIP1 antibody detects JIP1 protein at cytoplasm on mouse brain by immunoh...
Immunohistochemistry (IHC) image for anti-MAPK8IP1 Antikörper (Mitogen-Activated Protein Kinase 8 Interacting Protein 1) (Center) (ABIN2854806) IHC-P Image Immunohistochemical analysis of paraffin-embedded lung SCC xenograft, usi...