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pADPR Antikörper

Reaktivität: Alle Spezies IHC, ELISA, WB Wirt: Huhn Polyclonal unconjugated
Produktnummer ABIN2854260
  • Target
    pADPR
    Reaktivität
    Alle Spezies
    Wirt
    • 3
    Huhn
    Klonalität
    • 3
    Polyklonal
    Konjugat
    • 1
    • 1
    • 1
    Unkonjugiert
    Applikation
    • 3
    • 2
    • 2
    • 2
    Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
    Produktmerkmale
    Recognizes DNA-damage and apoptosis related poly-ADP ribosylated proteins and poly (ADP-ribose) polymer
    Aufreinigung
    Immunofractionation
    Immunogen
    poly(ADP-ribose)
    Isotyp
    IgY
  • Applikationshinweise
    WB 1 µg/mL,
    IH 1 µg/mL
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    PBS, pH 7.4 with 0,05 % sodium azides
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid freeze/thaw cycles.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Stable for 1 year from date of shipment when stored at -20 °C or -70 °C. Stable for at least 1 month at 4 °C.
  • Vyas, Chesarone-Cataldo, Todorova, Huang, Chang: "A systematic analysis of the PARP protein family identifies new functions critical for cell physiology." in: Nature communications, Vol. 4, pp. 2240, (2013) (PubMed).

    Yeh, Sbodio, Tsun, Luo, Chi: "Insulin-stimulated exocytosis of GLUT4 is enhanced by IRAP and its partner tankyrase." in: The Biochemical journal, Vol. 402, Issue 2, pp. 279-90, (2007) (PubMed).

    Xiao, Chen, Zsengellér, Li, Kiss, Kollai, Szabó: "Poly(ADP-Ribose) polymerase promotes cardiac remodeling, contractile failure, and translocation of apoptosis-inducing factor in a murine experimental model of aortic banding and heart failure." in: The Journal of pharmacology and experimental therapeutics, Vol. 312, Issue 3, pp. 891-8, (2005) (PubMed).

    Cover, Fickert, Knight, Fuchsbichler, Farhood, Trauner, Jaeschke: "Pathophysiological role of poly(ADP-ribose) polymerase (PARP) activation during acetaminophen-induced liver cell necrosis in mice." in: Toxicological sciences : an official journal of the Society of Toxicology, Vol. 84, Issue 1, pp. 201-8, (2005) (PubMed).

    Chang, Coughlin, Mitchison: "Tankyrase-1 polymerization of poly(ADP-ribose) is required for spindle structure and function." in: Nature cell biology, Vol. 7, Issue 11, pp. 1133-9, (2005) (PubMed).

    Chang, Jacobson, Mitchison: "Poly(ADP-ribose) is required for spindle assembly and structure." in: Nature, Vol. 432, Issue 7017, pp. 645-9, (2004) (PubMed).

    Szabó, Pacher, Zsengellér, Vaslin, Komjáti, Benkö, Chen, Mabley, Kollai: "Angiotensin II-mediated endothelial dysfunction: role of poly(ADP-ribose) polymerase activation." in: Molecular medicine (Cambridge, Mass.), Vol. 10, Issue 1-6, pp. 28-35, (2004) (PubMed).

    Xiao, Chen, Zsengellér, Szabó: "Poly(ADP-ribose) polymerase contributes to the development of myocardial infarction in diabetic rats and regulates the nuclear translocation of apoptosis-inducing factor." in: The Journal of pharmacology and experimental therapeutics, Vol. 310, Issue 2, pp. 498-504, (2004) (PubMed).

    Szabó, Soós, Bährle, Zsengellér, Flechtenmacher, Hagl, Szabó: "Role of poly(ADP-ribose) polymerase activation in the pathogenesis of cardiopulmonary dysfunction in a canine model of cardiopulmonary bypass." in: European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, Vol. 25, Issue 5, pp. 825-32, (2004) (PubMed).

    Szabó, Soós, Mandera, Heger, Flechtenmacher, Seres, Zsengellér, Sack, Szabó, Hagl: "Mesenteric injury after cardiopulmonary bypass: role of poly(adenosine 5'-diphosphate-ribose) polymerase." in: Critical care medicine, Vol. 32, Issue 12, pp. 2392-7, (2004) (PubMed).

    Obrosova, Pacher, Szabó, Zsengeller, Hirooka, Stevens, Yorek: "Aldose reductase inhibition counteracts oxidative-nitrosative stress and poly(ADP-ribose) polymerase activation in tissue sites for diabetes complications." in: Diabetes, Vol. 54, Issue 1, pp. 234-42, (2004) (PubMed).

  • Target
    pADPR
    Hintergrund
    Synonyms: poly(ADP-ribose)
    Poly(ADP-ribose) or pADPr is a polymer synthesized by a class of enzymes named poly(ADP-ribose) polymerase (PARP). Using NAD+ as substrate, PARP catalyzes the formation of the polymer pADPr, with chain lengths ranging from 2 to 300 residues, containing approximately 2 % branching in the chain. pADPr becomes attached to nuclear proteins, and to PARP itself (automodification).
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