APP Antikörper (N-Term)

Produktnummer ABIN285047

Produktdetails anti-APP Antikörper

Target: APP (Amyloid beta (A4) Precursor Protein (APP))

Bindungsspezifität: AA 44-63, N-Term

Reaktivität: Human

Wirt: Ziege

Klonalität: Polyklonal

Konjugat: Dieser APP Antikörper ist unkonjugiert

Applikation: ELISA

Immunogen: APP antibody was raised in goat using a synthetic peptide corresponding to amino acids 44-63 of the N-terminus of the alzheimer's disease APP as the immunogen.

Anwendungsinformationen

Applikationshinweise: ELISA: 1:5,000
Optimal conditions should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: Lot specific

Buffer: PBS, pH 7.4 with 0.05 % NaN3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium Azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handhabung: Avoid repeated freeze/thaw cycles.
Dilute only prior to immediate use.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 4 °C for short term storage. Aliquot and store at -20 °C for long term storage.

Referenzen für anti-APP Antikörper (ABIN285047)

Gasparini, Crowther, Martin, Berg, Coleman, Goedert, Spillantini: "Tau inclusions in retinal ganglion cells of human P301S tau transgenic mice: effects on axonal viability." in: Neurobiology of aging, Vol. 32, Issue 3, pp. 419-33, (2011) (PubMed).

Details zu APP

Target: APP (Amyloid beta (A4) Precursor Protein (APP))

Andere Bezeichnung: APP (APP Produkte)

Synonyme: AAA antikoerper, ABETA antikoerper, ABPP antikoerper, AD1 antikoerper, APPI antikoerper, CTFgamma antikoerper, CVAP antikoerper, PN-II antikoerper, PN2 antikoerper, aaa antikoerper, abeta antikoerper, abpp antikoerper, ad1 antikoerper, appi antikoerper, ctfgamma antikoerper, cvap antikoerper, pn2 antikoerper, APP antikoerper, APP-like antikoerper, APPL antikoerper, Abeta antikoerper, BcDNA:GH04413 antikoerper, CG7727 antikoerper, Dmel\\CG7727 antikoerper, EG:65F1.5 antikoerper, appl antikoerper, Abpp antikoerper, Adap antikoerper, Ag antikoerper, Cvap antikoerper, E030013M08Rik antikoerper, betaApp antikoerper, app antikoerper, wu:fj34d10 antikoerper, wu:fk65e12 antikoerper, zgc:85740 antikoerper, amyloid beta precursor protein antikoerper, amyloid beta (A4) precursor protein antikoerper, beta amyloid protein precursor-like antikoerper, amyloid beta (A4) precursor protein a antikoerper, amyloid beta precursor protein L homeolog antikoerper, APP antikoerper, app antikoerper, Appl antikoerper, App antikoerper, appa antikoerper, app.L antikoerper

Hintergrund: Amyloid precursor protein (APP) is an integral membrane protein expressed in many tissues and concentrated in the synapses of neurons. Its primary function is not known, though it has been implicated as a regulator of synapse formation, neural plasticity and iron export. APP is best known and most commonly studied as the precursor molecule whose proteolysis generates beta amyloid (ABeta), a 39- to 42-amino acid peptide whose amyloid fibrillar form is the primary component of amyloid plaques found in the brains of Alzheimer's disease patients.

Pathways: Caspase Kaskade in der Apoptose, EGFR Signaling Pathway, Transition Metal Ion Homeostasis, Skeletal Muscle Fiber Development, Toll-Like Receptors Cascades, Feeding Behaviour