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ERBB3 Antikörper (pTyr1289)

ERBB3 Reaktivität: Human WB, DB Wirt: Kaninchen Polyclonal RB25837 unconjugated
Produktnummer ABIN2839805
  • Target Alle ERBB3 Antikörper anzeigen
    ERBB3 (Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3))
    Bindungsspezifität
    • 29
    • 26
    • 21
    • 15
    • 15
    • 14
    • 12
    • 12
    • 8
    • 7
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pTyr1289
    Reaktivität
    • 193
    • 130
    • 113
    • 17
    • 6
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human
    Wirt
    • 194
    • 35
    • 1
    • 1
    Kaninchen
    Klonalität
    • 191
    • 40
    Polyklonal
    Konjugat
    • 118
    • 15
    • 10
    • 10
    • 10
    • 10
    • 10
    • 10
    • 6
    • 6
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    Dieser ERBB3 Antikörper ist unkonjugiert
    Applikation
    • 111
    • 72
    • 55
    • 53
    • 53
    • 32
    • 30
    • 28
    • 23
    • 17
    • 8
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Dot Blot (DB)
    Aufreinigung
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogen
    This ERBB3 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y1289 of human ERBB3.
    Klon
    RB25837
    Isotyp
    Ig Fraction
    Top Product
    Discover our top product ERBB3 Primärantikörper
  • Applikationshinweise
    WB: 1:1000. DB: 1:500
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Haltbarkeit
    6 months
  • Huang, Gao, Wang, McManaman, Thor, Yang, Esteva, Liu: "Heterotrimerization of the growth factor receptors erbB2, erbB3, and insulin-like growth factor-i receptor in breast cancer cells resistant to herceptin." in: Cancer research, Vol. 70, Issue 3, pp. 1204-14, (2010) (PubMed).

    Pierce, Ahsan: "Genetic susceptibility to type 2 diabetes is associated with reduced prostate cancer risk." in: Human heredity, Vol. 69, Issue 3, pp. 193-201, (2010) (PubMed).

    Carr, Niederer, Williams, Harper, Watts, Lyons, Smith: "Confirmation of the genetic association of CTLA4 and PTPN22 with ANCA-associated vasculitis." in: BMC medical genetics, Vol. 10, pp. 121, (2009) (PubMed).

    Zhang, Opresko, Shankaran, Chrisler, Wiley, Resat: "HER/ErbB receptor interactions and signaling patterns in human mammary epithelial cells." in: BMC cell biology, Vol. 10, pp. 78, (2009) (PubMed).

    Li, Feng, He: "Case-control study of association between the functional candidate gene ERBB3 and schizophrenia in Caucasian population." in: The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry, Vol. 10, Issue 4 Pt 2, pp. 595-8, (2009) (PubMed).

  • Target
    ERBB3 (Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3))
    Andere Bezeichnung
    ERBB3 (ERBB3 Produkte)
    Synonyme
    ErbB-3 antikoerper, HER3 antikoerper, LCCS2 antikoerper, MDA-BF-1 antikoerper, c-erbB-3 antikoerper, c-erbB3 antikoerper, erbB3-S antikoerper, p180-ErbB3 antikoerper, p45-sErbB3 antikoerper, p85-sErbB3 antikoerper, ERBB3 antikoerper, C76256 antikoerper, Erbb-3 antikoerper, Erbb3r antikoerper, Her3 antikoerper, nuc-ErbB3 antikoerper, erb-b2 receptor tyrosine kinase 3 antikoerper, v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) antikoerper, ERBB3 antikoerper, Erbb3 antikoerper
    Hintergrund
    This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form.
    Molekulargewicht
    148098
    NCBI Accession
    NP_001005915, NP_001973
    UniProt
    P21860
    Pathways
    RTK Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung
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