CHRNA9 Antikörper (N-Term)

Produktnummer ABIN2838559

Produktdetails anti-CHRNA9 Antikörper

Target: CHRNA9 (Cholinergic Receptor, Nicotinic, alpha 9 (Neuronal) (CHRNA9))

Bindungsspezifität: AA 8-42, N-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CHRNA9 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Flow Cytometry (FACS)

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This CHRNA9 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 8-42 amino acids from the N-terminal region of human CHRNA9.

Klon: RB46802

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000. FC: 1:25

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Referenzen für anti-CHRNA9 Antikörper (ABIN2838559)

Hillier, Graves, Fulton, Fulton, Pepin, Minx, Wagner-McPherson, Layman, Wylie, Sekhon, Becker, Fewell, Delehaunty, Miner, Nash, Kremitzki, Oddy, Du, Sun, Bradshaw-Cordum, Ali, Carter, Cordes, Harris et al.: "Generation and annotation of the DNA sequences of human chromosomes 2 and 4. ..." in: Nature, Vol. 434, Issue 7034, pp. 724-31, (2005) (PubMed).

Peng, Ferris, Matthews, Hiel, Lopez-Albaitero, Lustig: "Characterization of the human nicotinic acetylcholine receptor subunit alpha (alpha) 9 (CHRNA9) and alpha (alpha) 10 (CHRNA10) in lymphocytes." in: Life sciences, Vol. 76, Issue 3, pp. 263-80, (2004) (PubMed).

Lustig, Peng: "Chromosome location and characterization of the human nicotinic acetylcholine receptor subunit alpha (alpha) 9 (CHRNA9) gene." in: Cytogenetic and genome research, Vol. 98, Issue 2-3, pp. 154-9, (2003) (PubMed).

Sgard, Charpantier, Bertrand, Walker, Caput, Graham, Bertrand, Besnard: "A novel human nicotinic receptor subunit, alpha10, that confers functionality to the alpha9-subunit." in: Molecular pharmacology, Vol. 61, Issue 1, pp. 150-9, (2001) (PubMed).

Nguyen, Ndoye, Grando: "Novel human alpha9 acetylcholine receptor regulating keratinocyte adhesion is targeted by Pemphigus vulgaris autoimmunity." in: The American journal of pathology, Vol. 157, Issue 4, pp. 1377-91, (2000) (PubMed).

Details zu CHRNA9

Target: CHRNA9 (Cholinergic Receptor, Nicotinic, alpha 9 (Neuronal) (CHRNA9))

Andere Bezeichnung: CHRNA9 (CHRNA9 Produkte)

Synonyme: HSA243342 antikoerper, NACHRA9 antikoerper, 2410015I05Rik antikoerper, Acra9 antikoerper, EG666827 antikoerper, Gm8311 antikoerper, cholinergic receptor nicotinic alpha 9 subunit antikoerper, cholinergic receptor, nicotinic, alpha polypeptide 9 antikoerper, CHRNA9 antikoerper, Chrna9 antikoerper

Hintergrund: Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding may induce an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane. In the ear, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma. May also regulate keratinocyte adhesion.

Molekulargewicht: 54807

Gen-ID: 55584

UniProt: Q9UGM1

Pathways: Sensory Perception of Sound