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IRS4 Antikörper (AA 401-500) (Alexa Fluor 594)

IRS4 Reaktivität: Maus, Ratte IF (cc), IF (p) Wirt: Kaninchen Polyclonal Alexa Fluor 594
Produktnummer ABIN2814929
  • Target Alle IRS4 Antikörper anzeigen
    IRS4 (Insulin Receptor Substrate 4 (IRS4))
    Bindungsspezifität
    • 15
    • 14
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 401-500
    Reaktivität
    • 31
    • 22
    • 14
    Maus, Ratte
    Wirt
    • 35
    • 2
    • 1
    Kaninchen
    Klonalität
    • 36
    • 2
    Polyklonal
    Konjugat
    • 11
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    Dieser IRS4 Antikörper ist konjugiert mit Alexa Fluor 594
    Applikation
    • 25
    • 25
    • 22
    • 11
    • 6
    • 6
    • 4
    • 3
    • 2
    • 1
    Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Kreuzreaktivität
    Maus, Ratte
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from mouse IRS-4
    Isotyp
    IgG
    Top Product
    Discover our top product IRS4 Primärantikörper
  • Applikationshinweise
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Haltbarkeit
    12 months
  • Target
    IRS4 (Insulin Receptor Substrate 4 (IRS4))
    Andere Bezeichnung
    IRS-4 (IRS4 Produkte)
    Synonyme
    IRS4 antikoerper, irs-4 antikoerper, py160 antikoerper, IRS-4 antikoerper, PY160 antikoerper, irs2 antikoerper, irs2-a antikoerper, insulin receptor substrate 4 antikoerper, insulin receptor substrate 4 S homeolog antikoerper, IRS4 antikoerper, irs4 antikoerper, Irs4 antikoerper, irs4.S antikoerper
    Hintergrund

    Synonyms: Insulin receptor substrate 4, IRS-4, Phosphoprotein of 160 kDa, pp160

    Background: Acts as an interface between multiple growth factor receptors possessing tyrosine kinase activity, such as insulin receptor, IGF1R and FGFR1, and a complex network of intracellular signaling molecules containing SH2 domains. Involved in the IGF1R mitogenic signaling pathway. Promotes the AKT1 signaling pathway and BAD phosphorylation during insulin stimulation without activation of RPS6KB1 or the inhibition of apoptosis. Interaction with GRB2 enhances insulin-stimulated mitogen-activated protein kinase activity. May be involved in nonreceptor tyrosine kinase signaling in myoblasts. Plays a pivotal role in the proliferation/differentiation of hepatoblastoma cell through EPHB2 activation upon IGF1 stimulation. May play a role in the signal transduction in response to insulin and to a lesser extent in response to IL4 and GH on mitogenesis. Plays a role in growth, reproduction and glucose homeostasis. May act as negative regulators of the IGF1 signaling pathway by suppressing the function of IRS1 and IRS2.

    Gen-ID
    16370
    UniProt
    Q9Z0Y7
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