FAM3C Antikörper (AA 151-227) (Alexa Fluor 594)

Produktnummer ABIN2813084

Produktdetails anti-FAM3C Antikörper (Alexa Fluor 594)

Target: FAM3C (Family with Sequence Similarity 3, Member C (FAM3C))

Bindungsspezifität: AA 151-227

Reaktivität: Human, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FAM3C Antikörper ist konjugiert mit Alexa Fluor 594

Applikation: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Kreuzreaktivität: Human, Ratte

Homologie: Mouse,Dog,Cow,Pig,Horse,Chicken

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human FAM3C

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu FAM3C

Target: FAM3C (Family with Sequence Similarity 3, Member C (FAM3C))

Andere Bezeichnung: FAM3C (FAM3C Produkte)

Synonyme: ILEI antikoerper, D6Wsu176e antikoerper, Ilei antikoerper, wu:fb99h11 antikoerper, wu:fi35h03 antikoerper, zgc:55444 antikoerper, zgc:77090 antikoerper, family with sequence similarity 3 member C antikoerper, family with sequence similarity 3, member C antikoerper, family with sequence similarity 3 member C L homeolog antikoerper, fam3c antikoerper, FAM3C antikoerper, Fam3c antikoerper, fam3c.L antikoerper

Hintergrund:

Synonyms: Fam3c, FAM3C_HUMAN, family with sequence similarity 3, member C, GS3786,ILEI, Interleukin-like EMT inducer, Predicted osteoblast protein, Protein FAM3C.

Background: ILEI is a 227 amino acid, ubiquitously expressed protein containing an amino-terminal signal peptide. Elevated levels of ILEI translation are observed in oncogenic, Ras-transformed mammary epithelial cells and epithelial to mesenchymal transition (Emt) as well as tumor growth and metastasis. Also, overexpression of ILEI results in loss of ZO-1, a protein involved in tight junctions, and expression of cytoplasmic E-cadherin, which has been shown to influence loss of polarity and invasiveness. Due to this evidence, it is suspected that ILEI cooperates with oncogenic Ras to cause TGF-independent Emt and its overexpression is correlated with the invasion, metastasis and survival in a variety of cancers.

Gen-ID: 10447