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ADAM11 Antikörper (AA 351-450) (Alexa Fluor 594)

ADAM11 Reaktivität: Human, Maus WB, IF (cc), IF (p) Wirt: Kaninchen Polyclonal Alexa Fluor 594
Produktnummer ABIN2809449
  • Target Alle ADAM11 Antikörper anzeigen
    ADAM11 (ADAM Metallopeptidase Domain 11 (ADAM11))
    Bindungsspezifität
    • 14
    • 8
    • 7
    • 6
    • 2
    • 1
    AA 351-450
    Reaktivität
    • 38
    • 21
    • 6
    • 5
    Human, Maus
    Wirt
    • 36
    • 2
    Kaninchen
    Klonalität
    • 37
    • 1
    Polyklonal
    Konjugat
    • 10
    • 3
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser ADAM11 Antikörper ist konjugiert mit Alexa Fluor 594
    Applikation
    • 37
    • 18
    • 12
    • 12
    • 3
    • 3
    • 2
    • 1
    Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Kreuzreaktivität
    Human, Maus
    Homologie
    Rat,Cow,Sheep
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human ADAM11
    Isotyp
    IgG
    Top Product
    Discover our top product ADAM11 Primärantikörper
  • Applikationshinweise
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Haltbarkeit
    12 months
  • Target
    ADAM11 (ADAM Metallopeptidase Domain 11 (ADAM11))
    Andere Bezeichnung
    ADAM11 (ADAM11 Produkte)
    Synonyme
    DKFZp459F101 antikoerper, AW060611 antikoerper, Mdc antikoerper, MDC antikoerper, mdc antikoerper, mdc11a antikoerper, xMDC11 antikoerper, ADAM metallopeptidase domain 11 antikoerper, a disintegrin and metallopeptidase domain 11 antikoerper, ADAM metallopeptidase domain 11 L homeolog antikoerper, ADAM11 antikoerper, adam11 antikoerper, Adam11 antikoerper, adam11.L antikoerper
    Hintergrund

    Synonyms: A disintegrin and metalloproteinase domain 11, ADA11_HUMAN, MDC, Metalloproteinase like, disintegrin like, and cysteine rich protein.

    Background: ADAM11 was first described as MDC (Metalloproteinase-like disintergin-like cysteine-rich protein) from analysis of human brain libraries, in search of brain-specific proteins. Two splice variants with different carboxyterminal ends were described. The message was found only in the brain in this publication. Another group identified ADAM11 in the human brain, where ADAM11 was thought to be involved in cell migration and spatial patterning. ADAM11 was mapped to 17q21.3, a region of interest for breast cancer, and mutations in ADAM11 are associated with some breast cancers. Retinoic acid caused a doubling in ADAM11 message levels over 24 hours in NT2/D1 cells, a human embryonic carcinoma cell line. ADAM11 null mutant mice have deficits in spatial learning and motor coordination, although they did have normal cell migration and differentiation during development. ADAM11 is a member of the ADAMs family (A Disintegrin And Metalloproteinase), but does not contain the canonical HExxHxxxxH zinc-binding metalloproteinase catalytic site. The domain structure of the full-length ADAM11 includes a signal sequence, propeptide domain, metalloproteinase-like domain, disintegrin-like domain, cys-rich domain, EGF-like domain, a spacer region, then the transmembrane domain and a short cytoplasmic domain.

    Gen-ID
    4185
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