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MYLIP Antikörper (AA 65-103) (Alexa Fluor 594)

MYLIP Reaktivität: Human, Maus, Ratte WB, IF (p) Wirt: Kaninchen Polyclonal Alexa Fluor 594
Produktnummer ABIN2804421
  • Target Alle MYLIP Antikörper anzeigen
    MYLIP (Myosin Regulatory Light Chain Interacting Protein (MYLIP))
    Bindungsspezifität
    • 14
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 65-103
    Reaktivität
    • 35
    • 31
    • 22
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Maus, Ratte
    Wirt
    • 35
    • 2
    Kaninchen
    Klonalität
    • 35
    • 2
    Polyklonal
    Konjugat
    • 19
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser MYLIP Antikörper ist konjugiert mit Alexa Fluor 594
    Applikation
    • 33
    • 16
    • 14
    • 12
    • 7
    • 5
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Kreuzreaktivität
    Human, Maus, Ratte
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human MYLIP
    Isotyp
    IgG
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  • Applikationshinweise
    IF(IHC-P) 1:50-200
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Haltbarkeit
    12 months
  • Target
    MYLIP (Myosin Regulatory Light Chain Interacting Protein (MYLIP))
    Andere Bezeichnung
    MYLIP (MYLIP Produkte)
    Synonyme
    IDOL antikoerper, MIR antikoerper, 9430057C20Rik antikoerper, Mir antikoerper, mylip antikoerper, wu:fj36b03 antikoerper, zgc:55987 antikoerper, MYLIP antikoerper, mir antikoerper, zgc:153767 antikoerper, myosin regulatory light chain interacting protein antikoerper, myosin regulatory light chain interacting protein a antikoerper, myosin regulatory light chain interacting protein L homeolog antikoerper, myosin regulatory light chain interacting protein b antikoerper, MYLIP antikoerper, Mylip antikoerper, mylipa antikoerper, mylip.L antikoerper, mylip antikoerper, mylipb antikoerper
    Hintergrund

    Synonyms: MIR, IDOL, E3 ubiquitin-protein ligase MYLIP, Inducible degrader of the LDL-receptor, Myosin regulatory light chain interacting protein, MYLIP, BZF1, BM-023, PP5242

    Background: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of myosin regulatory light chain (MRLC), LDLR, VLDLR and LRP8. Activity depends on E2 enzymes of the UBE2D family. Proteasomal degradation of MRLC leads to inhibit neurite outgrowth in presence of NGF by counteracting the stabilization of MRLC by saposin-like protein (CNPY2/MSAP) and reducing CNPY2-stimulated neurite outgrowth. Acts as a sterol-dependent inhibitor of cellular cholesterol uptake by mediating ubiquitination and subsequent degradation of LDLR.

    Gen-ID
    29116
    UniProt
    Q8WY64
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