SHC3 Antikörper

Produktnummer ABIN1944948

Produktdetails anti-SHC3 Antikörper

Target: SHC3 (SHC (Src Homology 2 Domain Containing) Transforming Protein 3 (SHC3))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SHC3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB - 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Referenzen für anti-SHC3 Antikörper (ABIN1944948)

Humphray, Oliver, Hunt, Plumb, Loveland, Howe, Andrews, Searle, Hunt, Scott, Jones, Ainscough, Almeida, Ambrose, Ashwell, Babbage, Babbage, Bagguley, Bailey, Banerjee, Barker, Barlow, Bates, Beasley et al.: "DNA sequence and analysis of human chromosome 9. ..." in: Nature, Vol. 429, Issue 6990, pp. 369-74, (2004) (PubMed).

Liu, Meakin: "ShcB and ShcC activation by the Trk family of receptor tyrosine kinases." in: The Journal of biological chemistry, Vol. 277, Issue 29, pp. 26046-56, (2002) (PubMed).

Nakamura, Sanokawa, Sasaki, Ayusawa, Oishi, Mori: "N-Shc: a neural-specific adapter molecule that mediates signaling from neurotrophin/Trk to Ras/MAPK pathway." in: Oncogene, Vol. 13, Issue 6, pp. 1111-21, (1996) (PubMed).

Pelicci, Dente, De Giuseppe, Verducci-Galletti, Giuli, Mele, Vetriani, Giorgio, Pandolfi, Cesareni, Pelicci: "A family of Shc related proteins with conserved PTB, CH1 and SH2 regions." in: Oncogene, Vol. 13, Issue 3, pp. 633-41, (1996) (PubMed).

Details zu SHC3

Target: SHC3 (SHC (Src Homology 2 Domain Containing) Transforming Protein 3 (SHC3))

Andere Bezeichnung: SHC3 (SHC3 Produkte)

Synonyme: N-Shc antikoerper, NSHC antikoerper, RAI antikoerper, SHCC antikoerper, ShcC antikoerper, Rai antikoerper, SHC adaptor protein 3 antikoerper, src homology 2 domain-containing transforming protein C3 antikoerper, SHC3 antikoerper, Shc3 antikoerper

Hintergrund: Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons.
Synonyms: SHC-transforming protein 3, Neuronal Shc, N-Shc, Protein Rai, SHC-transforming protein C, Src homology 2 domain-containing-transforming protein C3, SH2 domain protein C3, SHC3, NSHC, SHCC

Molekulargewicht: 64056 Da

Gen-ID: 53358

UniProt: Q92529

Pathways: RTK Signalweg, EGFR Signaling Pathway, Neurotrophin Signalübertragung