MCL-1 Antikörper

Produktnummer ABIN1944902

Produktdetails anti-MCL-1 Antikörper

Target: MCL-1 (MCL1) (Induced Myeloid Leukemia Cell Differentiation Protein Mcl-1 (MCL1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MCL-1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:1000. WB: 1:1000. IHC: 1:50-1:100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Lagerung: 4 °C,-20 °C

Referenzen für anti-MCL-1 Antikörper (ABIN1944902)

Akgul, Turner, White, Edwards: "Functional analysis of the human MCL-1 gene." in: Cellular and molecular life sciences : CMLS, Vol. 57, Issue 4, pp. 684-91, (2000) (PubMed).

Bingle, Craig, Swales, Singleton, Zhou, Whyte: "Exon skipping in Mcl-1 results in a bcl-2 homology domain 3 only gene product that promotes cell death." in: The Journal of biological chemistry, Vol. 275, Issue 29, pp. 22136-46, (2000) (PubMed).

Umezawa, Maruyama, Inazawa, Imai, Takano, Hata: "Induction of mcl1/EAT, Bcl-2 related gene, by retinoic acid or heat shock in the human embryonal carcinoma cells, NCR-G3." in: Cell structure and function, Vol. 21, Issue 2, pp. 143-50, (1996) (PubMed).

Details zu MCL-1

Target: MCL-1 (MCL1) (Induced Myeloid Leukemia Cell Differentiation Protein Mcl-1 (MCL1))

Andere Bezeichnung: MCL1 (MCL1 Produkte)

Synonyme: BCL2L3 antikoerper, EAT antikoerper, MCL1-ES antikoerper, MCL1L antikoerper, MCL1S antikoerper, Mcl-1 antikoerper, TM antikoerper, bcl2-L-3 antikoerper, mcl1/EAT antikoerper, AW556805 antikoerper, mcl-1 antikoerper, fb72f02 antikoerper, wu:fb70a08 antikoerper, wu:fb72f02 antikoerper, zfMLP1 antikoerper, zfMcl-1a antikoerper, zgc:109835 antikoerper, zgc:109763 antikoerper, E3 antikoerper, E3-2 antikoerper, RNE3 antikoerper, RNU107 antikoerper, SNORA63A antikoerper, elF-4AII antikoerper, MCL1, BCL2 family apoptosis regulator antikoerper, myeloid cell leukemia sequence 1 antikoerper, MCL1, BCL2 family apoptosis regulator a antikoerper, MCL1, BCL2 family apoptosis regulator b antikoerper, small nucleolar RNA, H/ACA box 63 antikoerper, MCL1 antikoerper, Mcl1 antikoerper, mcl1a antikoerper, mcl1b antikoerper, SNORA63 antikoerper

Hintergrund: Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis.

Molekulargewicht: 37337 Da

Gen-ID: 4170

UniProt: Q07820

Pathways: MAPK Signalweg