NR2F2 Antikörper (N-Term)

Produktnummer ABIN2792599

Produktdetails anti-NR2F2 Antikörper

Target: NR2F2 (Nuclear Receptor Subfamily 2, Group F, Member 2 (NR2F2))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus, Ratte, Hund, Rind (Kuh), Schwein, Kaninchen, Zebrafisch (Danio rerio), Schaf

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NR2F2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Sequenz: KVGMRREAVQ RGRMPPTQPT HGQFALTNGD PLNCHSYLSG YISLLLRAEP

Kreuzreaktivität: Rind (Kuh), Hund, Huhn, Human, Maus, Schwein, Ratte (Rattus)

Homologie: Cow: 92%, Dog: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%, Sheep: 92%, Zebrafish: 92%

Produktmerkmale: This is a rabbit polyclonal antibody against NR2F2. It was validated on Western Blot and immunohistochemistry.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human NR2F2

Anwendungsinformationen

Applikationshinweise: WB Suggested Anti-NR2F2 Antibody Titration: 0.2-1 µg/mL
ELISA Titer: 1:312500
Positive Control: Transfected 293T.
Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 414 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-NR2F2 Antikörper (ABIN2792599)

Déjardin, Kingston: "Purification of proteins associated with specific genomic Loci." in: Cell, Vol. 136, Issue 1, pp. 175-86, (2009) (PubMed).

Details zu NR2F2

Target: NR2F2 (Nuclear Receptor Subfamily 2, Group F, Member 2 (NR2F2))

Andere Bezeichnung: NR2F2 (NR2F2 Produkte)

Synonyme: nr2f2 antikoerper, MGC52954 antikoerper, ARP1 antikoerper, COUPTFB antikoerper, COUPTFII antikoerper, NF-E3 antikoerper, NR2F1 antikoerper, SVP40 antikoerper, TFCOUP2 antikoerper, 2700033K02Rik antikoerper, 9430015G03Rik antikoerper, ARP-1 antikoerper, Aporp1 antikoerper, COUP-TF2 antikoerper, COUP-TFII antikoerper, EAR3 antikoerper, Tcfcoup2 antikoerper, Tfcoup2 antikoerper, fc94g08 antikoerper, svp40 antikoerper, svp[40] antikoerper, wu:fc94g08 antikoerper, nuclear receptor subfamily 2 group F member 2 L homeolog antikoerper, Nr2f2 protein antikoerper, nuclear receptor subfamily 2 group F member 2 antikoerper, nuclear receptor subfamily 2, group F, member 2 antikoerper, nr2f2.L antikoerper, nr2f2 antikoerper, NR2F2 antikoerper, Nr2f2 antikoerper

Hintergrund: NR2F2, an orphan member of the nuclear hormone receptor superfamily, acts as a transcriptional repressor by antagonizing the functions of other nuclear hormone receptors and by actively silencing transcription. However, in certain contexts, NR2F2 stimulates transcription directly. NR2F2, MyoD and p300 interact in a competitive manner, and that increasing amounts of NR2F2 have the ability to reduce the interaction between myoD and p300 invitro. NR2F2 post-transcriptionally regulates myoD activity/function, and that crosstalk between orphan nuclear receptors and the myogenic bHLH proteins has functional consequences for differentiation.
Alias Symbols: ARP1, COUP-TFII, COUPTFB, MGC117452, SVP40, TFCOUP2, NF-E3, NR2F1, COUPTFII
Protein Interaction Partner: NSD1, BCL11A, NR2F2, BIK, SETD7, FAM46A, HIPK3, UBC, TFAP4, Cebpb, SMARCAD1, NR2F6, POU5F1, NR3C1, PHB2, TRIP4, PIAS1, BCL11B, TRIM24, EP300, SQSTM1, HDAC1, NCOR2, MYOD1, LCK,
Protein Size: 414

Molekulargewicht: 45 kDa

Gen-ID: 7026

NCBI Accession: NM_021005, NP_066285

UniProt: P24468

Pathways: Steroid Hormone Mediated Signaling Pathway