p65 Antikörper (Nuclear Factor-KB P65) (N-Term)

Details for Product anti-NFkBP65 Antibody No. ABIN2792581, Anbieter: Anmelden zum Anzeigen
Antigen
  • C-Rel
  • NFKB3
  • p65
  • NFkB
  • REL proto-oncogene, NF-kB subunit
  • RELA proto-oncogene, NF-kB subunit
  • v-rel reticuloendotheliosis viral oncogene homolog A (avian)
  • REL
  • RELA
  • Rela
  • Rel
Epitop
N-Term
130
84
67
63
49
44
40
38
38
37
26
26
25
18
17
16
15
15
13
13
13
12
11
10
9
8
7
6
6
4
4
4
4
4
4
4
4
4
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reaktivität
Rind (Kuh), Meerschweinchen, Pferd, Human, Maus, Ratte (Rattus), Zebrafisch
1138
652
505
72
55
55
30
25
24
23
12
8
8
6
3
2
1
1
Wirt
Kaninchen
995
130
17
11
1
1
Klonalität
Polyklonal
Konjugat
Dieser p65 Antikörper ist unkonjugiert
30
28
22
20
18
18
17
13
12
12
12
8
8
8
8
8
8
8
8
4
4
3
3
2
2
2
2
2
2
1
Applikation
Western Blotting (WB)
833
430
325
260
199
163
105
90
88
28
19
18
15
12
12
6
6
6
5
5
4
2
2
2
1
Optionen
Hersteller
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Hersteller Produkt- Nr.
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Immunogen The immunogen is a synthetic peptide directed towards the N terminal region of human RELA
Sequenz VEIIEQPKQR GMRFRYKCEG RSAGSIPGER STDTTKTHPT IKINGYTGPG
Kreuzreaktivität Rind (Kuh), Hund, Huhn, Human, Maus, Schwein, Ratte (Rattus)
Homologie Cow: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rat: 100%, Zebrafish: 92%
Produktmerkmale This is a rabbit polyclonal antibody against RELA. It was validated on Western Blot using a cell lysate as a positive control.
Reinigung Protein A purified
Andere Bezeichnung RELA / NF-kB p65 (NFkBP65 Antibody Abstract)
Hintergrund P65 is a subunit of the nuclear factor kappa-B, a second messenger, which activates the transcription of a number of genes in multiple tissues. The inhibitory effect of I-kappa-B upon NF-kappa-B in the cytoplasm is exerted primarily through the interaction with p65. p65 shows a weak DNA-binding site which could contribute directly to DNA binding in the NF-kappa-B complex.
Alias Symbols: p65, NFKB3
Protein Interaction Partner: GAN, CCND1, ABCA1, UBC, TCF4, SRSF7, RELA, REL, PRKDC, PLG, PEX1, NFKB2, NFKB1, MUC3A, KRT5, REV1, TXN2, FBXW11, IL1RN, IKBKB, HSPA5, HDAC1, EP300, CREBBP, MAP3K8, CHEK1, CDKN2A, CDK4, SPATA31A3, POTEJ, POTEE, PIWIL4, DIS3L2, DCD, IKBKG, CHUK, PLA2G4A, ST
Protein Size: 551
Molekulargewicht 60 kDa
Gen-ID 5970
NCBI Accession NM_021975, NP_068810
UniProt Q04206
Pathways NF-kappaB Signalweg, RTK Signalweg, T-Zell Rezeptor Signalweg, TLR Signalweg, Fc-epsilon Rezeptor Signalübertragung, Neurotrophin Signalübertragung, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Hepatitis C, Toll-Like Receptors Cascades
Applikationshinweise WB Suggested Anti-RELA Antibody Titration: 1.0 µg/mL
ELISA Titer: 1:62500
Positive Control: HepG2 cell lysate.
Optimal working dilutions should be determined experimentally by the investigator.
Kommentare

Antigen size: 551 AA

Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration Lot specific
Buffer Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung Avoid repeated freeze-thaw cycles.
Lagerung -20 °C
Informationen zur Lagerung For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Bilder des Herstellers
Western Blotting (WB) image for anti-Nuclear Factor-KB P65 (NFkBP65) (N-Term) antibody (ABIN2792581) WB Suggested Anti-RELA Antibody Titration: 1.0ug/ml
ELISA Titer: 1:6...
Allgemeine Veröffentlichungen Ruben, Dillon, Schreck, Henkel, Chen, Maher, Baeuerle, Rosen: "Isolation of a rel-related human cDNA that potentially encodes the 65-kD subunit of NF-kappa B." in: Science (New York, N.Y.), Vol. 251, Issue 5000, pp. 1490-3, 1991 (PubMed).

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