DOK1 Antikörper (C-Term)

Produktnummer ABIN2792206

Produktdetails anti-DOK1 Antikörper

Target: DOK1 (Docking Protein 1, 62kDa (Downstream of tyrosine Kinase 1) (DOK1))

Bindungsspezifität: C-Term

Reaktivität: Human, Pferd

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DOK1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: EPGTATGSGI KSHNSALYSQ VQKSGASGSW DCGLSRVGTD KTGVKSEGST

Homologie: Horse: 84%, Human: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against DOK1. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human DOK1

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 481 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu DOK1

Target: DOK1 (Docking Protein 1, 62kDa (Downstream of tyrosine Kinase 1) (DOK1))

Andere Bezeichnung: DOK1 (DOK1 Produkte)

Synonyme: P62DOK antikoerper, Dok-1 antikoerper, AW557123 antikoerper, p62DOK antikoerper, dok1 antikoerper, zgc:76914 antikoerper, docking protein 1 antikoerper, docking protein 1b antikoerper, DOK1 antikoerper, Dok1 antikoerper, dok1b antikoerper

Hintergrund: DOK1 is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210(bcr/abl), a chimeric protein whose presence is associated with CML. DOK1 contains a putative pleckstrin homology domain at the amino terminus and ten PXXP SH3 recognition motifs. Docking protein 2 binds p120 (RasGAP) from CML cells. It has been postulated to play a role in mitogenic signaling.Docking protein 1 is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210(bcr/abl), a chimeric protein whose presence is associated with CML. Docking protein 1 contains a putative pleckstrin homology domain at the amino terminus and ten PXXP SH3 recognition motifs. Docking protein 2 binds p120 (RasGAP) from CML cells. It has been postulated to play a role in mitogenic signaling.
Alias Symbols: MGC117395, MGC138860, P62DOK
Protein Interaction Partner: UBC, RASA1, ABL1, CD28, Nck1, Syngap1, INSR, CRKL, BCR, Dlg4, gag-pol, ERBB2, VAV1, SRC, SHC1, PTK6, PIK3R1, ITK, FGR, CRK, ABL2, CBLL1, INPP5D, NCK2, MAP4K4, PTPRH, GRB10, TEC, ITGB2, SH2D1A, FES, PTPN6, ITGB3, PLCG1, LYN, KIT, YES1, RET, LCK, ITGB5, ITG
Protein Size: 481

Molekulargewicht: 53 kDa

Gen-ID: 1796

NCBI Accession: NM_001381, NP_001372

UniProt: Q99704