MDM4-binding Protein Antikörper (N-Term)

Produktnummer ABIN2792185

Produktdetails anti-MDM4-binding Protein Antikörper

Target: MDM4-binding Protein (MDM4) (Mdm4-binding Protein (MDM4))

Bindungsspezifität: N-Term

Reaktivität: Human, Rind (Kuh), Schwein, Kaninchen, Hund, Pferd

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MDM4-binding Protein Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: IPSQDQLKQS AEESSTSRKR TTEDDIPTLP TSEHKCIHSR EDEDLIENLA

Homologie: Cow: 80%, Dog: 93%, Horse: 93%, Human: 100%, Pig: 86%, Rabbit: 80%

Produktmerkmale: This is a rabbit polyclonal antibody against MDM4. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human MDM4

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 490 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-MDM4-binding Protein Antikörper (ABIN2792185)

Schlaeger, Longerich, Schiller, Bewerunge, Mehrabi, Toedt, Kleeff, Ehemann, Eils, Lichter, Schirmacher, Radlwimmer: "Etiology-dependent molecular mechanisms in human hepatocarcinogenesis." in: Hepatology (Baltimore, Md.), Vol. 47, Issue 2, pp. 511-20, (2008) (PubMed).

Details zu MDM4-binding Protein

Target: MDM4-binding Protein (MDM4) (Mdm4-binding Protein (MDM4))

Andere Bezeichnung: MDM4 (MDM4 Produkte)

Synonyme: mdmx antikoerper, HDMX antikoerper, MDMX antikoerper, MRP1 antikoerper, wu:fa09h09 antikoerper, wu:fi33d10 antikoerper, 4933417N07Rik antikoerper, AA414968 antikoerper, AL023055 antikoerper, AU018793 antikoerper, AU021806 antikoerper, C85810 antikoerper, Mdmx antikoerper, MDM4, p53 regulator S homeolog antikoerper, MDM4, p53 regulator antikoerper, transformed mouse 3T3 cell double minute 4 antikoerper, mdm4.S antikoerper, MDM4 antikoerper, Mdm4 antikoerper, mdm4 antikoerper

Hintergrund: MDM4 inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. It inhibits degradation of MDM2. It can reverse MDM2-targeted degradation of p53 while maintaining suppression of p53 transactivation and apoptotic functions. The human MDM4 gene, which plays a role in apoptosis, encodes a 490-amino acid protein containing a RING finger domain and a putative nuclear localization signal. The MDM4 putative nuclear localization signal, which all Mdm proteins contain, is located in the C-terminal region of the protein. The mRNA is expressed at a high level in thymus and at lower levels in all other tissues tested. MDM4 protein produced by in vitro translation interacts with p53 via a binding domain located in the N-terminal region of the MDM4 protein. MDM4 shows significant structural similarity to p53-binding protein MDM2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: DKFZp781B1423, MDMX, MGC132766, MRP1, HDMX
Protein Interaction Partner: RNF115, CAPN7, CD160, MDM2, TP53, UBC, MDM4, USP2, YWHAG, UBE2D2, PRKAA1, BCL2, RPS20, RPS15, RPL37, YWHAQ, HSP90AA1, CSNK1A1, PPP1CC, PPP1CB, PPP1CA, RB1, APP, UBE2D3, UBE2D1, MNAT1, ABL1, LRSAM1, TRIM55, TRIM46, MKRN3, YWHAZ, YWHAE, YWHAB, CDKN1A, RFWD2
Protein Size: 490

Molekulargewicht: 55 kDa

Gen-ID: 4194

NCBI Accession: NM_002393, NP_002384

UniProt: O15151

Pathways: Zellzyklus