TNFSF10 Antikörper (Tumor Necrosis Factor (Ligand) Superfamily, Member 10) (N-Term)

Details for Product anti-TNFSF10 Antibody No. ABIN2792132, Anbieter: Anmelden zum Anzeigen
Antigen
  • TRAIL
  • tl2
  • apo2l
  • cd253
  • trail
  • apo-2l
  • trail1
  • xtrail1
  • APO2L
  • Apo-2L
  • CD253
  • TL2
  • A330042I21Rik
  • AI448571
  • APO-2L
  • Ly81
  • Trail
  • tumor necrosis factor (ligand) superfamily, member 10
  • TNF-related apoptosis inducing ligand-like
  • TNFSF10
  • TRAIL-LIKE
  • tnfsf10
  • Tnfsf10
Epitop
N-Term
41
26
15
7
6
5
5
4
4
3
3
3
3
2
2
1
1
1
1
1
1
1
1
1
1
1
Reaktivität
Hund, Human, Schwein
321
74
34
2
2
2
1
1
1
Wirt
Kaninchen
190
153
24
2
1
Klonalität
Polyklonal
Konjugat
Dieser TNFSF10 Antikörper ist unkonjugiert
38
21
14
10
5
5
4
4
3
3
3
3
3
3
3
3
3
2
2
1
1
1
1
1
1
1
1
1
1
Applikation
Western Blotting (WB)
238
117
114
53
49
28
17
14
13
13
10
8
4
2
2
2
2
2
1
1
1
1
1
Optionen
Hersteller
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Hersteller Produkt- Nr.
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Immunogen The immunogen is a synthetic peptide directed towards the N terminal region of human TNFSF10
Sequenz CFLKEDDSYW DPNDEESMNS PCWQVKWQLR QLVRKMILRT SEETISTVQE
Homologie Dog: 80%, Human: 100%, Pig: 78%
Produktmerkmale This is a rabbit polyclonal antibody against TNFSF10. It was validated on Western Blot using a cell lysate as a positive control.
Reinigung Affinity Purified
Andere Bezeichnung TNFSF10 (TNFSF10 Antibody Abstract)
Hintergrund TNFSF10 is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3.
Alias Symbols: TL2, APO2L, CD253, TRAIL, Apo-2L
Protein Interaction Partner: CASP8, CASP3, CFLAR, TNFRSF10B, FADD, RIPK1, TRAF2, TNFAIP3, SOCS3, RBM48, TNFRSF10D, TNFRSF10C, TNFRSF10A, TNFSF10, TNFRSF11B, ACP5, IER3, CREBBP, SP3, SP1, HDAC5, HDAC4, HDAC3, HDAC2, HDAC1, HIST3H3,
Protein Size: 281
Molekulargewicht 33 kDa
Gen-ID 8743
NCBI Accession NM_003810, NP_003801
UniProt P50591
Pathways Apoptose, Positive Regulation of Endopeptidase Activity
Applikationshinweise Optimal working dilution should be determined by the investigator.
Kommentare

Antigen size: 281 AA

Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration Lot specific
Buffer Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung Avoid repeated freeze-thaw cycles.
Lagerung -20 °C
Informationen zur Lagerung For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Bilder des Herstellers
Western Blotting (WB) image for anti-Tumor Necrosis Factor (Ligand) Superfamily, Member 10 (TNFSF10) (N-Term) antibody (ABIN2792132) WB Suggested Anti-TNFSF10 Antibody Titration: 0.2-1 ug/ml
Positive Contr...
Produkt verwendet in: Ceballos, Parody, Quiroga, Casella, Francés, Larocca, Carnovale, Alvarez, Carrillo: "FoxO3a nuclear localization and its association with β-catenin and Smads in IFN-α-treated hepatocellular carcinoma cell lines." in: Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, Vol. 34, Issue 11, pp. 858-69, 2014 (PubMed).

Allgemeine Veröffentlichungen Wu, Tsai, Lin, Chou, Chen, Yang, Hsu, Hsu: "Helicobacter pylori enhances tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis in human gastric epithelial cells." in: World journal of gastroenterology : WJG, Vol. 10, Issue 16, pp. 2334-9, 2004 (PubMed).

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