ASAP2 Antikörper (N-Term)

Produktnummer ABIN2790909

Produktdetails anti-ASAP2 Antikörper

Target: ASAP2 (ArfGAP with SH3 Domain, Ankyrin Repeat and PH Domain 2 (ASAP2))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus, Ratte, Pferd, Hund, Kaninchen, Schwein, Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ASAP2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: LSTDLHTIKQ AQDEERRQLI QLRDILKSAL QVEQKEDSQI RQSTAYSLHQ

Homologie: Dog: 100%, Horse: 93%, Human: 100%, Mouse: 93%, Pig: 93%, Rabbit: 78%, Rat: 93%, Zebrafish: 93%

Produktmerkmale: This is a rabbit polyclonal antibody against ASAP2. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of Human ASAP2

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 1006 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu ASAP2

Target: ASAP2 (ArfGAP with SH3 Domain, Ankyrin Repeat and PH Domain 2 (ASAP2))

Andere Bezeichnung: ASAP2 (ASAP2 Produkte)

Synonyme: DDEF2 antikoerper, ddef2 antikoerper, asap2 antikoerper, si:dkey-37o8.2 antikoerper, AMAP2 antikoerper, CENTB3 antikoerper, PAG3 antikoerper, PAP antikoerper, Pap-alpha antikoerper, SHAG1 antikoerper, 6530401G17Rik antikoerper, Ddef2 antikoerper, Gm1523 antikoerper, Gm592 antikoerper, ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 antikoerper, ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 L homeolog antikoerper, ArfGAP with SH3 domain, ankyrin repeat and PH domain 1b antikoerper, ASAP2 antikoerper, asap2.L antikoerper, asap1b antikoerper, asap2 antikoerper, Asap2 antikoerper

Hintergrund: This gene encodes a multidomain protein containing an N-terminal alpha-helical region with a coiled-coil motif, followed by a pleckstrin homology (PH) domain, an Arf-GAP domain, an ankyrin homology region, a proline-rich region, and a C-terminal Src homology 3 (SH3) domain. The protein localizes in the Golgi apparatus and at the plasma membrane, where it colocalizes with protein tyrosine kinase 2-beta (PYK2). The encoded protein forms a stable complex with PYK2 in vivo. This interaction appears to be mediated by binding of its SH3 domain to the C-terminal proline-rich domain of PYK2. The encoded protein is tyrosine phosphorylated by activated PYK2. It has catalytic activity for class I and II ArfGAPs in vitro, and can bind the class III Arf ARF6 without immediate GAP activity. The encoded protein is believed to function as an ARF GAP that controls ARF-mediated vesicle budding when recruited to Golgi membranes. In addition, it functions as a substrate and downstream target for PYK2 and SRC, a pathway that may be involved in the regulation of vesicular transport.
Alias Symbols: AMAP2, CENTB3, DDEF2, PAG3, PAP, Pap-alpha, SHAG1
Protein Interaction Partner: SH3KBP1, MAP1LC3A, CTTN, Asap1, IKBKG, UBC, SUMO1, ELAVL1, ITSN1, THSD7A, GRB2, PACSIN3, PXN, BIN1, PTK2B, RAN, ARF6, REPS2, ARF5, ARF1, SRC, TBRG4,
Protein Size: 1006

Molekulargewicht: 112 kDa

Gen-ID: 8853

NCBI Accession: NM_003887, NP_003878

UniProt: O43150