SPAM1 Antikörper (C-Term)

Produktnummer ABIN2789782

Produktdetails anti-SPAM1 Antikörper

Target: SPAM1 (Sperm Adhesion Molecule 1 (PH-20 Hyaluronidase, Zona Pellucida Binding) (SPAM1))

Bindungsspezifität: C-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SPAM1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: CYSTLSCKEK ADVKDTDAVD VCIADGVCID AFLKPPMETE EPQIFYNASP

Homologie: Human: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against SPAM1. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human SPAM1

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 509 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu SPAM1

Target: SPAM1 (Sperm Adhesion Molecule 1 (PH-20 Hyaluronidase, Zona Pellucida Binding) (SPAM1))

Andere Bezeichnung: SPAM1 (SPAM1 Produkte)

Synonyme: AV039194 antikoerper, Ph-20 antikoerper, PH-20 antikoerper, PH20 antikoerper, HYA1 antikoerper, HYAL1 antikoerper, HYAL3 antikoerper, HYAL5 antikoerper, SPAG15 antikoerper, Spam antikoerper, XEH1 antikoerper, spam1 antikoerper, im:6902904 antikoerper, zgc:158668 antikoerper, sperm adhesion molecule 1 antikoerper, sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding) L homeolog antikoerper, sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding) antikoerper, Spam1 antikoerper, SPAM1 antikoerper, spam1.L antikoerper, spam1 antikoerper

Hintergrund: Hyaluronidase degrades hyaluronic acid, a major structural proteoglycan found in extracellular matrices and basement membranes. Six members of the hyaluronidase family are clustered into two tightly linked groups on chromosome 3p21.3 and 7q31.3. This gene was previously referred to as HYAL1 and HYA1 and has since been assigned the official symbol SPAM1, another family member on chromosome 3p21.3 has been assigned HYAL1. This gene encodes a GPI-anchored enzyme located on the human sperm surface and inner acrosomal membrane. This multifunctional protein is a hyaluronidase that enables sperm to penetrate through the hyaluronic acid-rich cumulus cell layer surrounding the oocyte, a receptor that plays a role in hyaluronic acid induced cell signaling, and a receptor that is involved in sperm-zona pellucida adhesion. Abnormal expression of this gene in tumors has implicated this protein in degradation of basement membranes leading to tumor invasion and metastasis. Multiple transcript variants encoding different isoforms have been found for this gene.
Alias Symbols: HYA1, HYAL1, HYAL3, HYAL5, MGC26532, PH-20, PH20, SPAG15
Protein Size: 509

Molekulargewicht: 58 kDa

Gen-ID: 6677

NCBI Accession: NM_153189, NP_694859

UniProt: P38567