Macrophage Scavenger Receptor 1 Antikörper (N-Term)
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- Target Alle Macrophage Scavenger Receptor 1 (MSR1) Antikörper anzeigen
- Macrophage Scavenger Receptor 1 (MSR1)
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Bindungsspezifität
- N-Term
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Reaktivität
- Human, Schwein, Hund, Rind (Kuh), Pferd
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser Macrophage Scavenger Receptor 1 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB)
- Sequenz
- VSSTNANDIT QSLTGKGNDS EEEMRFQEVF MEHMSNMEKR IQHILDMEAN
- Homologie
- Cow: 82%, Dog: 93%, Horse: 85%, Human: 100%, Pig: 82%
- Produktmerkmale
- This is a rabbit polyclonal antibody against MSR1. It was validated on Western Blot.
- Aufreinigung
- Affinity Purified
- Top Product
- Discover our top product MSR1 Primärantikörper
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- Applikationshinweise
- Optimal working dilutions should be determined experimentally by the investigator.
- Kommentare
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Antigen size: 451 AA
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handhabung
- Avoid repeated freeze-thaw cycles.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- Macrophage Scavenger Receptor 1 (MSR1)
- Andere Bezeichnung
- MSR1 (MSR1 Produkte)
- Synonyme
- CD204 antikoerper, SCARA1 antikoerper, SR-A antikoerper, SRA antikoerper, phSR1 antikoerper, phSR2 antikoerper, MRS-A antikoerper, MSR antikoerper, MSR-A antikoerper, SR-AI antikoerper, SR-AII antikoerper, Scara1 antikoerper, Scvr antikoerper, MSR1 antikoerper, RGD1564316 antikoerper, macrophage scavenger receptor 1 antikoerper, scavenger receptor class A member 5 antikoerper, MSR1 antikoerper, Msr1 antikoerper, SCARA5 antikoerper
- Hintergrund
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This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages.
Alias Symbols: CD204, SCARA1, SR-A, phSR1, phSR2, SRA
Protein Interaction Partner: SEC22A, LEPROTL1, MALL, NKG7, ATP6V0C, IQCB1, TRAF6, HSPA1A,
Protein Size: 451 - Molekulargewicht
- 50 kDa
- Gen-ID
- 4481
- NCBI Accession
- NM_138715, NP_619729
- UniProt
- P21757
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