GCK Antikörper (N-Term)
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- Target Alle GCK Antikörper anzeigen
- GCK (Glucokinase (Hexokinase 4) (GCK))
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Bindungsspezifität
- N-Term
- Reaktivität
- Human, Maus, Ratte, Rind (Kuh), Schaf, Kaninchen, Meerschweinchen, Hund, Pferd
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser GCK Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB)
- Sequenz
- RVMLVKVGEG EEGQWSVKTK HQMYSIPEDA MTGTAEMLFD YISECISDFL
- Homologie
- Cow: 93%, Dog: 100%, Guinea Pig: 100%, Horse: 93%, Human: 100%, Mouse: 93%, Rabbit: 100%, Rat: 100%, Sheep: 93%
- Produktmerkmale
- This is a rabbit polyclonal antibody against GCK. It was validated on Western Blot.
- Aufreinigung
- Affinity Purified
- Top Product
- Discover our top product GCK Primärantikörper
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- Applikationshinweise
- Optimal working dilutions should be determined experimentally by the investigator.
- Kommentare
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Antigen size: 464 AA
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handhabung
- Avoid repeated freeze-thaw cycles.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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Anti-diabetes effect of chronic intermittent hypobaric hypoxia through improving liver insulin resistance in diabetic rats." in: Life sciences, Vol. 150, pp. 1-7, (2016) (PubMed).
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Anti-diabetes effect of chronic intermittent hypobaric hypoxia through improving liver insulin resistance in diabetic rats." in: Life sciences, Vol. 150, pp. 1-7, (2016) (PubMed).
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- Target
- GCK (Glucokinase (Hexokinase 4) (GCK))
- Andere Bezeichnung
- GCK (GCK Produkte)
- Synonyme
- FGQTL3 antikoerper, GK antikoerper, GLK antikoerper, HHF3 antikoerper, HK4 antikoerper, HKIV antikoerper, HXKP antikoerper, LGLK antikoerper, MODY2 antikoerper, Gk antikoerper, Gls006 antikoerper, GCK antikoerper, BA4487 antikoerper, glk antikoerper, hk4 antikoerper, hhf3 antikoerper, hkiv antikoerper, hxkp antikoerper, gck-A antikoerper, mody2 antikoerper, glucokinase antikoerper, GLUKA antikoerper, RNGK2 antikoerper, glucokinase antikoerper, glucokinase (hexokinase 4) L homeolog antikoerper, glucokinase (hexokinase 4) antikoerper, GCK antikoerper, Gck antikoerper, glcK antikoerper, Bphyt_1025 antikoerper, Halhy_6548 antikoerper, gk antikoerper, gck.L antikoerper, gck antikoerper
- Hintergrund
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Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. Alternative splicing of this gene results in three tissue-specific forms of glucokinase, one found in pancreatic islet beta cells and two found in liver. The protein localizes to the outer membrane of mitochondria. In contrast to other forms of hexokinase, this enzyme is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. Mutations in this gene have been associated with non-insulin dependent diabetes mellitus (NIDDM), maturity onset diabetes of the young, type 2 (MODY2) and persistent hyperinsulinemic hypoglycemia of infancy (PHHI).
Alias Symbols: FGQTL3, GK, GLK, HHF3, HK4, HKIV, HXKP, MODY2, LGLK
Protein Interaction Partner: PCNA, GCKR, INS, PFKFB2, MIG1,
Protein Size: 464 - Molekulargewicht
- 51 kDa
- Gen-ID
- 2645
- NCBI Accession
- NM_033508, NP_277043
- Pathways
- MAPK Signalweg, Positive Regulation of Peptide Hormone Secretion, Carbohydrate Homeostasis, Cellular Glucan Metabolic Process, Regulation of Carbohydrate Metabolic Process
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